Duphaston for mastopathy: the therapeutic effect of using the drug

Mastopathy is the general name for a group of common pathologies of the mammary glands that occur against the background of hormonal imbalance, and can occur in all representatives of the fair sex starting from adolescence. Various drugs are used to treat pathology, one of them is Duphaston.

Despite the absence of direct instructions in the instructions, Duphaston is often prescribed for the treatment of pathological changes in the mammary glands

About mastopathy

This is a fairly large group of pathological changes in mammary gland tissue, which can be conditionally divided according to the morphology of changes in the organ into two types: diffuse mastopathy and fibrocystic. They can be combined - the presence of nodules and cystic formations in the mammary gland does not exclude the detection of signs of diffuse changes there.

It should be remembered that some forms of mastopathy are precancerous conditions, so you should not self-medicate or not treat at all.

In the vast majority of clinical cases, the development of diffuse or cystic mastopathy is associated with the following provoking factors:

Patients with a history of family history are at greater risk of developing mastopathy.

• imbalance in the functioning of the endocrine system (thyroid disease, diabetes mellitus, disruption of the production of sex hormones);
• chronic and acute diseases of the female genital area;
• stress and excessive physical activity;
• abortions.

The symptoms of mastopathy are generally quite sparse: patients complain of discomfort or tenderness in the mammary glands, self-palpation may reveal areas of compaction or nodules, sometimes discharge from the nipples and breast engorgement before menstruation are observed.

The need to use hormonal agents, such as Duphaston, for mastopathy is dictated by the occurrence of hormonal imbalance.

Mastopathy often accompanies irregularities in the menstrual cycle, as the cause of these situations is a violation of hormone levels

Restoration of the normal menstrual cycle, as well as treatment of concomitant pathologies, lead to the elimination of the symptoms of diffuse or fibrocystic mastopathy.

Features of Duphaston

This drug belongs to the hormonal group and is a substance similar to natural progesterone, but acting more narrowly.

Duphaston affects exclusively the uterine endometrium and vaginal mucosa, while it does not suppress the ovulatory cycle at all, so pregnancy is quite possible against the background of its use.

Due to Duphaston's regulation of the menstrual cycle, the likelihood of pregnancy even increases

The drug is absorbed quickly from the gastrointestinal tract, and within 30–85 minutes its maximum concentration in the blood is reached. Most of the active substance of Duphaston is excreted in the form of metabolites in the urine.

It should be noted that the use of this medication in the treatment regimen retains the ability to assess the level of one’s own progesterone. This is due to the fact that Duphaston is excreted as dihydrodidrosterone, while progesterone produced in the body is assessed by the amount of pregnanediol in the urine.

Duphaston can be used during pregnancy, as it does not have any negative effect on the fetus, but this should be done only according to indications. At the same time, the drug is not approved for use in pediatric practice and during the lactation period (Duphaston is excreted in small quantities into breast milk).

If you are breastfeeding, you will have to refuse treatment with Duphaston.

Since Duphaston can cause drowsiness, you should work with complex machinery or drive a car with caution. It is advisable that several hours pass after taking the pill.

Duphaston is produced in the form of tablets containing 10 mg of the active substance (dydrogesterone). The medication is recommended for oral use only.

Indications for use

According to the instructions for use, the list of pathologies for which the use of Duphaston is recommended is as follows:

• infertility due to luteal insufficiency;

Duphaston is most often used in obstetric and gynecological practice.

• dysmenorrhea and menstrual irregularities;
• risk of miscarriage;
• habitual miscarriage;
• endometriosis;
• dysfunctional uterine bleeding;
• prevention of endometrial hyperplasia in menopause;
• secondary amenorrhea.

Having read the annotation for the drug, many ask a reasonable question: is it possible to take Duphaston for fibrocystic or diffuse mastopathy, since this disease is not on the list of indications?

Self-prescription of Duphaston without determining hormonal levels is prohibited

You can take this drug for cystic mastopathy or any other form of this pathology, but only if Duphaston is prescribed by the attending physician, who sees good reasons for this.

Contraindications and adverse reactions

Duphaston, like any other medication, has a number of contraindications. This medication should not be used in women with intolerance to the active ingredient (dydrogesterone) or excipients, as well as people suffering from liver failure. Duphaston is not recommended for the following pathologies:

• neoplasms dependent on the level of sex hormones;
• vaginal bleeding of unknown origin;

The drug is not prescribed for the treatment of bleeding with an unknown cause, and is also suspended if bleeding begins due to it.

• thrombophilia;
• galactose intolerance.

Important! If a woman is simultaneously taking other medications containing progesterone analogues, then Duphaston is not prescribed.

Most often, among the adverse reactions, patients note:

• headache;
• pain or discomfort in the mammary glands;
• menstrual irregularities;
• nausea.

In rare cases, taking Duphaston can cause emotional fluctuations

Sometimes there are complaints of drowsiness and depressed mood, abdominal discomfort and yellowness of the skin. Weight gain, which many women fear when starting to take hormonal medications, is rare. Several cases of hemolytic anemia have been reported while taking the drug, as well as an increase in the size of pregestagen-dependent tumors (for example, meningiomas).

Features of application

In the first months of treatment with Duphaston, scanty bleeding may appear, however, if they appear after the end of the course, you should definitely contact a gynecologist. Sometimes the use of this medication may be associated with the appearance or worsening of symptoms of herpes, otosclerosis, itching and cholestatic jaundice.

During the period of treatment with Duphaston, the previously “dormant” herpes virus in the body may become active.

Treatment with Duphaston should be stopped if the patient is concerned about the following conditions:

• severe headaches;
• development of venous thromboembolism;
• symptoms of cerebral ischemia;
• significant increase in blood pressure;
• often recurrent depression.

The use of Duphaston in postmenopausal patients may be associated with a slight increase in the risk of ischemic stroke, so this medicine should be used with caution in older age groups.

Middle-aged and elderly patients taking Duphaston should be under close medical attention

Important! You should regularly undergo preventive medical examinations and mammography, this is especially important while taking hormonal medications.

The dosage of Duphaston is selected by the doctor individually and depends on the clinical situation.

Interaction with other medications

Duphaston is not recommended to be combined with the prescription of anticonvulsants (Carbamazepine, Phenobarbital, etc.) and some antibiotics (Efavirenz, Rifampicin, etc.), as well as with drugs based on St. John's wort. Taking Duphaston together with these drugs accelerates its elimination from the body.

Simultaneous use of infusions or decoctions of St. John's wort with Duphaston can reduce the effect of the latter

With parallel treatment with Duphaston and Ritonavir or Nelfinavir, a decrease in the effectiveness of the hormonal drug is also observed.

Since hormonal therapy may be associated with an increased risk of thromboembolism, before recommending Duphaston to patients who are forced to constantly take anticoagulant drugs, the doctor should assess the risk/benefit ratio of such a prescription.

Analogs

Duphaston is a synthetic equivalent of progesterone, but lacks some of the systemic effects characteristic of the natural hormone. There are no analogues that are absolutely identical to Duphaston, but there are quite a lot of medications based on progestogens.

Utrozhestan is similar in action to Duphaston, but has some features

If necessary, in the treatment regimen for mastopathy or other conditions associated with progesterone deficiency, Duphaston can be replaced with the drug Utrozhestan, which contains pure progesterone in its composition. It is worth noting that it is not possible to assess the level of endogenous progesterone during treatment with Utrozhestan - the drug and its own hormone form the same metabolites.

Under no circumstances should you replace medications yourself. If the pharmacy does not have Duphaston, you should contact your doctor so that he changes the prescription and recommends another remedy.

For advice from a pharmacist on how to take Duphaston correctly, watch the video below:

Source: http://bolezni.com/stati-o-boleznyah/mastopatiya/dyufaston-pri-mastopatii.html

How effective is the drug Duphaston for mastopathy: principle of action and reviews from women

• Drugs used to treat mastopathy must be selected individually in each case: taking into account the form and degree of development of the disease, age and individual characteristics of the patient, and their action is aimed at eliminating the influence of provoking factors influencing the development of the pathology.
• Medicines used for effective treatment: hormonal and non-hormonal, can be either synthetic analogues or consist of natural components of plant and animal origin.
• Hormonal drugs used to treat mastopathy are considered the most effective, since they eliminate, first of all, the cause of the pathology, normalizing the balance of hormones in the female body.
• One of these drugs widely used to treat the disease is Duphaston, a synthesized analogue of progesterone.

The essence of pathology

Mastopathy is the general name for many pathological processes of the female mammary glands, which arise mainly against the background of hormonal imbalance and can appear in the fair sex at any age, starting from adolescence.

1. The disease causes discomfort and is quite painful sensations for a woman, in addition, the pathology, in case of untimely treatment, progresses and increases the risk of developing an oncological process.

2. The number of identified cases of the disease increases every year - the reason for this is a change in the lifestyle and behavior of women associated with the modern pace of life.

3. The disease manifests itself in the growth of glandular tissue of the mammary gland and the formation of multiple benign cysts - without timely treatment, the pathology begins to progress, painful symptoms intensify, which affects not only the general well-being of the woman, but also radically changes her usual way of life.

4. In addition, the pathological process can degenerate into an oncological disease, so every woman needs not only to promptly treat the disease, but also to carry out preventive measures aimed at preventing its occurrence.

5. Some forms of mastopathy are precancerous conditions - only a doctor can determine the degree of pathology, so you should not self-medicate or ignore the need for therapy - this can allow the development of quite serious and, sometimes, very disastrous complications .

The drug Duphaston and its action

• The drug belongs to hormonal drugs and contains a substance similar to natural progesterone (a hormone produced by the ovaries and adrenal glands and responsible for the menstrual cycle and pregnancy in women), which, when entering the woman’s body, performs similar functions.
• Since mastopathy, in most cases, occurs precisely because of a lack of progesterone, which leads to pathological growth of breast tissue, normalization of hormonal levels stops the further development of the disease.
• Duphaston blocks gland receptors at the cellular level, stopping its growth - this occurs due to the activation of estrogen.
• In addition, taking synthetic progesterone reduces pain in the affected breast; restores the functioning of the female reproductive system; reduces swelling of breast tissue and normalizes the course of premenstrual syndrome.

“Drugs for treatment should only be prescribed by a specialist, since most medications have side effects. The drug Duphaston for mastopathy reduces the pathological effect of estrogens on breast tissue, but, nevertheless, has side effects - sweating, palpitations, dizziness and digestive disorders.

For what types is it effective?

You can take the drug Duphaston for various forms of mastopathy (cystic, diffuse and fibrocystic) only if the attending physician has established its need.

Operating principle

1. Mastopathy is the result of hormonal imbalance: distortion of the natural levels of estrogen, progesterone and gestagens provokes pathological proliferation of breast tissue.

2. The action of the substance included in Duphaston increases the level of gestagens, which equalizes the ratio between other hormones.

3. In addition, the drug promotes:

• transformation and rejection of the endometrium (inner layer of the uterus), resulting in menstrual bleeding;
• reduces the frequency of uterine contractions, which prevents miscarriage;
• accelerates and normalizes the volume of substances in a woman’s body;
• normalizes vaginal microflora.

Indications for use

Duphaston is widely used by obstetricians and gynecologists, as it helps maintain pregnancy and normalize a woman’s menstrual function.

Indications for taking the drug are:

• soreness and feeling of heaviness in the mammary gland before menstruation;
• diffuse and fibrocystic mastopathy;
• focal formations (fibroadenomas) - but with caution!

How to take it correctly, dosage

The drug Duphaston is available in the form of small tablets intended for oral administration.

Previously, hormonal drugs for women were synthesized from male sex hormones, so the use of the drug caused a number of undesirable effects in women:

• deepening of the voice;
• male pattern hair growth;
• disruption of metabolic processes.

Thanks to the artificial analogue of progesterone contained in Duphaston, the drug is well tolerated by women and does not cause androgenic side effects.

The drug is absorbed within 30-60 minutes from the gastrointestinal tract, and excess drugs are excreted from the body along with urine.

Course duration

For mastopathy, Duphaston is used according to the standard regimen - the course of treatment is from 3 to 6 months, as hormone replacement therapy in combination with estrogens:

• continuous treatment regimen - 1 tablet per day, for 2 weeks of a 28-day menstrual cycle;
• cyclic use - 1 tablet of Duphaston in the last two weeks of taking estrogen medications.

Any treatment regimen must be selected and monitored by the attending physician - after the results of a control ultrasound or biopsy, if the response is inadequate, the dosage of the drug can be increased.

Contraindications for use

Contraindications to taking the drug Duphaston are the individual characteristics of patients:

1. Personal intolerance to the components of the drug (both dydrogesterone and excipients).
2. Patients with acute liver failure.
3. In case of detected malignant neoplasms developing as a result of hormonal imbalance.
4. In case of uterine bleeding (if bleeding occurs while taking Duphaston, then use of the drug should be stopped).
5. Thrombophilia and vascular problems.

With great caution, the drug is prescribed to patients with:

• arterial hypertension; diabetes mellitus;
• epilepsy;
• bronchial asthma and central nervous system disorders.

Duphaston should be taken with caution by women who drive a car and whose work requires increased concentration (the effect of the drug causes drowsiness).

Side effects

At first, a woman may experience bleeding from the vagina, which goes away on its own after some time. If the discharge does not stop, or becomes more abundant, then taking Duphaston should be stopped.

According to the results of research by scientists, the drug Duphaston is well tolerated by patients, but sometimes women still experience unwanted reactions:

• exacerbation of otosclerosis;
• herpes;
• itching;
• headache;
• nausea and some pain and discomfort in the mammary glands.

• Often, after taking the drug, women complain of constant drowsiness and depressed mood, as well as digestive disorders.
• Weight gain that accompanies taking hormonal medications when using Duphaston is quite rare..
• Cases of hemolytic anemia are also rare.

Reviews from women

Conclusion and conclusions

1. Duphaston is a synthetic gestagen that is successfully used in the treatment of mastopathy.
2. Regular courses of the drug help stop the progression of pathology and reduce lesions.
3. This medicine has its own contraindications and certain dosage regimens.
4. Therefore, taking Duphaston should be determined by necessity and monitored by the attending physician.

Source: https://zhenskoe-zdorovye.com/mammologija/mastopatiya/lechenie-mas/dyufaston-tabletki.html

Is it possible to take duphaston in the treatment of mastopathy, features of use of the drug

HomeTreatment and preventionIs it possible to take duphaston in the treatment of mastopathy, features of using the drug

The formation of lumps, tumors, cysts, nodes in mastopathy is a consequence of hormonal disorders in the female body. Early diagnosis and adequate treatment help to avoid disease progression and more severe consequences, including breast cancer. To effectively treat the disease, hormonal and non-hormonal drugs are used. The first are the most effective, since their action is aimed directly at the cause of the development of pathology - eliminating hormonal imbalance.

Duphaston is a synthesized progesterone analogue

The consequence of insufficient production of progesterone, which is one of the most important hormones, can be not only the proliferation of connective tissue (mastopathy), but also the development of infertility in women. Taking the French hormonal drug Duphaston will help to avoid this problem. It is an analogue of progesterone artificially synthesized in the laboratory.

The active substance, the dydrogesterone molecule, has similar properties to the natural hormone. Therefore, when it enters a woman’s female body, it performs the same functions.

Duphaston is available in the form of small white tablets intended for oral administration. The product contains:

• dydrogesterone 10 mg;
• lactose monohydrate;
• methylhydroxypropylcellulose;
• corn starch;
• Opadry Y-1-1000 white – acts as a dye;
• colloidal silicon dioxide, anhydrous;
• Magnesium stearate.

Action of Duphaston

The function of progesterone synthesis in the female body is performed by the corpus luteum, which appears after ovulation. If its functioning is disrupted, insufficiency occurs in the second phase of the menstrual cycle. This causes hormonal imbalance and the appearance of pathologies in the female body.

Mastopathy is the result of such a disharmonious disorder.

A distortion in the ratio of the amounts of estrogens, gestagens and the predominance of prolactin leads to uneven growth of mammary gland tissue, in which the glandular or stromal components predominate.

Progesterone partially performs the function of blocking estrogens, which are responsible for the intensity of mammary gland growth. Therefore, its deficiency affects the fulfillment of the restraining mission, which leads to the development of mastopathy.

In the described situation, taking Duphaston, an artificial progesterone drug, is the best way out. Under its action, the level of gestagens increases and the ratio of hormones is normalized.

The effect of Duphaston on the condition of the mammary glands

Duphaston and mastopathy are mutually exclusive concepts. In pathology of the mammary glands, gestagens directly affect changes in breast tissue. Taking synthetic progesterone affects:

• the size of cysts and lumps in the mammary gland (the growth of pathologically altered benign tissue stops or slows down);
• reducing the severity of pain;
• the state of the whole body – the functioning of the female reproductive system is normalized;
• reduction of swelling of mammary gland tissue;
• makes the course of premenstrual syndrome less painful.

Features of the drug

It should be noted that the previously used hormonal drugs that replaced progesterone were synthesized from male sex hormones. Because of this, the use of the drug gave a number of unpleasant side effects.

Women who took the drug experienced a noticeable deepening of the timbre of their voices, hair began to grow in areas characteristic of the male type, and metabolic processes were disrupted. One of the greatest advantages of Duphaston, which the manufacturer emphasizes, is the absence of androgenic side effects; the drug is well tolerated by the female body.

Once in the gastrointestinal tract, the medicine is quickly absorbed. The maximum concentration of the substance in the blood is observed 30-80 minutes after administration. The drug is excreted from the body in the urine.

Experts often recommend taking Duphaston to treat mastopathy and regulate hormonal balance in pregnant women for the reason that the drug is not able to have a negative effect on the growth and development of the fetus. And during lactation, the drug should not be used - a small amount of the synthetic hormone can pass into the baby through breast milk.

Reviews indicate that taking the drug may cause drowsiness.

Therefore, you can start performing activities that require increased concentration a few hours after taking the pill.

During the first time you take Duphaston, you may experience a small amount of discharge containing blood. After a short time they stop. If the discharge does not stop with the end of taking the drug, the woman should inform the treating gynecologist about this. Also, treatment with Duphaston can provoke an exacerbation of signs of otosclerosis, herpes, itching, etc.

How to take Duphaston

Treatment of cystic or fibrous mastopathy with Duphaston, as well as other hormone-dependent diseases, should be carried out as prescribed by a doctor. Only a specialist can evaluate the results of a patient’s study and decide on the need to use a particular drug.

As a rule, Duphaston is recommended to be taken for hormone replacement therapy along with estrogens:

• For continuous treatment - 1 tablet (10 mg) per day. Continue taking the medicine for 2 weeks within one 28-day menstrual cycle.
• When taking estrogens cyclically - 1 tablet (10 mg) during the last 2 weeks of taking estrogen.

If the results of control studies (ultrasound or biopsy) indicate an inadequate response to the drug, it is necessary to increase the dose of dydrogesterone by another 10 mg (up to 20 mg).

According to your request also read

Source: http://mastomed.ru/lechenie-i-profilaktika/djufaston-pri-mastopatii.html

Duphaston in the treatment of various types of mastopathy

25.01.2017

Pathological changes in the mammary glands are observed in many women; the disease is called mastopathy. According to statistics, women who have crossed the 40-year-old threshold are at risk. Simply put, if a woman has a hormonal imbalance, there is a high probability of developing a disease.

Necessary diagnostics for prescribing medications

The medical term mastopathy is collective and implies a group of diseases associated with the mammary glands.

Mastopathy is mainly divided into two types:

1. nodular form, which is treated by surgery;
2. fibrocystic form, can be treated conservatively.

To determine the form of mastopathy, you will have to undergo a series of diagnostic measures. The examination begins with palpation and a blood test. It is recommended to examine the mammary glands in the first phase of the menstrual cycle.

The doctor also conducts an external examination of the breast, assessing its appearance, asymmetry of contours, position of the nipples and color of the skin.
Palpation is carried out in a standing and lying position. The doctor must palpate the armpits and lymph nodes.

If a doctor suspects that a woman has mastopathy, he will refer her for mammography, radiography and ultrasound. In the nodular form, a cytological examination of the punctate is performed.

If a woman has concomitant diseases, she will have to undergo additional examinations from other doctors. Consultations with an endocrinologist, gynecologist or therapist are usually required.

In any case, conservative or medicinal treatment is aimed at eliminating pain and restoring hormonal levels. Medicines are also aimed at preventing the appearance and development of cancer, and reducing tumors in the breast.

Drugs for the treatment of mastopathy

As a rule, for fibrocystic mastopathy, two types of drugs are used - non-hormonal and hormonal.
The first group includes enzyme preparations and vitamin complexes. They achieve the best effect in the treatment of fibrocystic disease.

When choosing hormonal medications, the main thing is the correct and individual selection of the treatment regimen and specific medication.

Duphaston drug

Duphaston showed good results in treatment, especially in combination with homeopathic medicines.

pharmachologic effect

The active substance in the drug is dydrogesterone, which is an analogue of natural progesterone. Taking duphaston does not affect metabolism and does not change thermogenesis, therefore, it does not affect ovulation.

Quickly and well absorbed into the gastrointestinal tract.
It is concentrated in the blood within two hours after administration, and after 72 it is excreted from the body. Available in tablet form.

Indications for use

In addition to treating mastopathy, the medicine is suitable as replacement therapy for surgical castration and menopause. In some cases, it is prescribed for the threat of fetal loss and menstrual irregularities.

Methods of administration

When prescribing a treatment regimen, the natural phase of the natural menstrual cycle and the clinical manifestations of the pathology are taken into account.
You can take duphaston by dividing the daily dose into several doses throughout the day. Attention! It is recommended to use the drug after an equal amount of time.

Side effects

Rarely, breakthrough bleeding occurs. But the dose of the drug in this case is not canceled, but rather increased. Some women may be intolerant to dydrogesterone.

Contraindications

In the presence of Rotor and Dabin-Johnson syndrome, the drug is not prescribed. The drug is not recommended for liver diseases. Use with caution in case of renal failure and epilepsy.

During pregnancy, the drug can be used, but not during breastfeeding, since dydrogesterone passes into breast milk.
It does not affect the mental state of a woman, so it does not interfere with driving a vehicle.

Interaction with other drugs

In practice, no incompatibility has been observed when using the drug. Clinical effectiveness may be decreased when combined with phenobarbital.

Overdose

If this happens, then gastric lavage is used.

How does a woman feel after duphaston?

Despite such a short list of side effects in the instructions for use, some women treating mastopathy after duphaston experience nausea, headache, and dizziness. Some patients note that they experience bloating and slight bleeding in the periods between menstruation. Breast sensitivity often increases.

It is generally accepted that duphaston does not provide a contraceptive effect. However, this is a misconception, because the drug is completely synthetic and has a cumulative effect. Over time, after taking the drug for a long time, the pituitary gland slows down and ovulation stops.

Combination therapy

Along with hormonal therapy, topical medications can be used.

Api-bust

This drug is available in the form of a cream, and has not only a cosmetic effect. The cream affects the stimulation of metabolic processes in the mammary glands, regenerates and restores muscle tissue. The product is easy to use: apply a thin layer once a day. May cause allergies if a woman is intolerant to bee products.

Progestogel

Refers to drugs for topical use. The drug is based on progesterone for mastopathy, which helps reduce its symptoms. The drug is available in the form of a gel, and its structure does not allow the sex hormone to penetrate into the blood, which minimizes the occurrence of side effects.

Vitamin therapy

Complex treatment of mastopathy involves vitamin therapy. Vitamins help enhance the effect of other medications taken. They weaken their side effects and normalize the functioning of the immune system, which is very important for any disease. Vitamins A, B and E are used to treat mastopathy.

To relieve puffiness, vitamins C and P are used, which are found in large quantities in food products. For example, in citrus fruits, cherries, rose hips and raspberries.

Phytotherapy

Herbal treatment along with hormonal drugs is recommended by many. Especially if a woman has problems at the psycho-emotional level. It is recommended to drink tinctures of motherwort or valerian as sedatives.

Evening primrose oil and twig extract have been proven to be effective.

Cyclodinone and Mastodinone

To eliminate the imbalance between progesterol and estradiol, drugs based on twig extract are approved.
The drug Cyclodinone contains a high concentration of twigs, since it is a single drug. Mastodinon contains less twig, but there are 5 more homeopathic components aimed at eliminating the symptoms of mastopathy and improving women's health.

Intolerance to these drugs is extremely rare.

Prevention

It is important for any woman to monitor her health throughout her life.

Prevention is based on several rules:

1. avoid stressful situations as much as possible;
2. avoid tanning in direct sunlight;
3. have regular sex life;
4. feed the child for at least 5 months;
5. give birth to your first child before age 25.

Also, a woman should independently examine her mammary glands for the appearance of lumps and regularly visit a doctor.

Source: http://zenmd.su/lechenie-mastopatii-dyufastonom/

How is the drug Duphaston used for mastopathy? Can everyone drink it?

Mastopathy is a benign pathology of the mammary glands, which brings a lot of discomfort if it progresses and is not treated in a timely manner. The number of new identified cases increases annually, which is associated with changes in the lifestyle and behavior of women.

Treatment of mastopathy includes herbal preparations, vitamins, alternative medicine methods (leeches, dietary supplements, homeopathy and others), as well as hormonal agents. The latter are increasingly used due to their effectiveness and the emergence of scientific justification for their action. How does duphaston affect mastopathy, what are its indications and contraindications for use?

Effect of the drug on the body

In recent years, there has been a lot of controversy about the benefits and harms of duphaston and similar gestagen-based medications, especially with regard to taking the medicine during pregnancy. But definitely, its use does not leave its mark on the body, and if there is an initial pathology, it may well help to overcome or slow down the development of the disease.

Duphaston contains dydrogesterone. This is a synthetic resemblance to natural progesterone, which is synthesized in a woman’s body. It has minimal corticoid, estrogenic and androgenic effects.

Progesterone is normally synthesized by the corpus luteum, which is formed after ovulation. When its function is weak or pathological secretion, insufficiency of the second phase of the menstrual cycle occurs. And hence the various changes in the female body.

Mastopathy is a consequence of an imbalance of sex hormones.

An imbalance between estrogens and gestagens and an increase in the amount of prolactin leads to uneven tissue growth in the mammary glands with a predominance of stromal or glandular components.

Taking artificial progesterone, the level of gestagens in a woman’s body increases, which equalizes the ratio between hormones. Therefore, you shouldn’t even think about whether duphaston can be used for mastopathy.

So, we can note the following effect of gestagen (including the one contained in the drug) on ​​the body:

• Promotes secretory transformation of the inner layer of the uterus in the second phase of the cycle. After this, the endometrium is rejected and menstruation begins.
• Under their influence, the number of uterine contractions decreases, which is important during pregnancy to prevent the threat of miscarriage.
• Metabolism accelerates, which is reflected in an increase in body temperature in the second phase of the cycle. This is especially noticeable when measuring it in the rectum or vagina (basal). At the same time, intensive formation of adipose tissue occurs.
• Progestins have a diuretic effect, stimulating the excretion of sodium while leaving potassium in the body.
• Promotes the necessary changes in the vaginal epithelium, as a result of which the required pH level is maintained.

Watch the video about the action of the drug:

Effect of the drug on the mammary glands

Gestagens have a direct effect on the growth and development of breast tissue. When taking synthetic progesterone, you can expect the following effects on a woman’s body, which is important in the presence of breast pathology:

• Treatment with duphaston leads to the regulation of menstrual function and an increase in the level of gestagens. All this reduces the speed and degree of proliferative changes in the mammary glands. Observations confirm that in women there is a decrease in compaction and size of cysts in the tissues of the mammary glands. Mastopathy, especially common forms, will not go away completely, but such treatment can slow down the progression of the disease.
• Additional doses of gestagens, affecting the overall balance of hormones in the body, lead to a decrease in the production of estrogen. Namely, they are responsible for excessive tissue growth and the formation of mastopathy foci. Thus, this process is improved and the disease, at a minimum, does not progress.
• Duphaston affects the entire body, not just the mammary glands. By helping to normalize the functioning of the female reproductive system, it also counteracts the development of mastopathy. After all, breast pathology is a reflection of the health of the whole body, especially the pelvic organs.
• Reduces the permeability of capillaries to the liquid component of blood, which leads to a decrease in swelling of the lobules and the disappearance of pain.

Indications for use

Duphaston is widely used in obstetric and gynecological practice. It helps maintain pregnancy, normalize menstrual function, etc. Its analogues are also used - utrozhestan, susten, prozhestogel and others.

Duphaston began to be used for the treatment of mastopathy relatively recently, after a positive effect was noticed in women who regularly take gestagens for other reasons.

Indications for use in cases of breast pathology:

• Premenstrual syndrome with engorgement and tenderness in the breasts. As well as discomfort in the mammary glands throughout the entire cycle.
• Diffuse mastopathy with a predominance of glandular or stromal components.
• In the treatment of focal formations, for example, fibroadenomas, one should be very careful. First, it is first necessary to exclude malignant growth. Secondly, in focal forms of mastopathy, duphaston has the least significant effect.

Contraindications

Duphaston is one of the safest hormonal drugs with the fewest side effects. It should not be taken if hypersensitivity to such drugs has previously been noted.

Due to the fact that the drug is metabolized in the liver, it is necessary to take it with extreme caution in case of liver pathology, for example, with Dubin-Johnson syndrome, etc.

• It should also be borne in mind that some medications can change the effect of administration, for example, phenobarbital and the like.
• The drug can only be used if prescribed by a doctor for varicose veins and a history of thrombosis.
• Is it possible to drink duphaston for mastopathy? You should check with your doctor individually if you have arterial hypertension, migraines, diabetes, epilepsy and some other diseases of the central nervous system, as well as bronchial asthma and kidney dysfunction.

A course of treatment

Duphaston for fibrocystic mastopathy is used in most cases according to one standard regimen. Tablets should be taken 10 mg 2 times a day. Treatment should begin on the 14th day of the cycle for two weeks. After withdrawal, menstrual-like bleeding appears. The general course is from three to six months.

Sometimes, instead of duphaston, its analogue is used - the natural gestagen utrozhestan. There is no fundamental difference in the action of these two drugs, therefore the regimen is standard. Only in the case of utrogestan, the required dosage is 100 mg, also twice a day.

Duphaston analogues used for the treatment of mastopathy

In the treatment of benign pathology of the mammary glands, in addition to duphaston, other analogue drugs are also used, including in other forms, for example, in the form of a gel.

The most common are the following:

• Utrozhestan,
• susten,
• progester.

In their action, all analogues are almost identical. But some have more, others less, side effects and intolerance.

Often women are interested in what is better - duphaston or utrozhestan for mastopathy. Sometimes their use is absolutely identical, at least there is no data on different degrees of therapeutic effect.

Utrozhestan often causes a decrease in blood pressure, has a calming effect in addition, and sometimes dizziness is observed. This is the only complete analogue of natural progesterone; all others have some differences in their chemical structure.

Progestogel is available in the form of a gel for local application to the skin of the mammary glands. The advantage of the drug is that it has virtually no systemic absorption, which makes it possible to use it even for liver and kidney pathologies. The gel is applied twice a day, the duration of treatment is determined by the doctor, taking into account the clinical situation.

We recommend reading the article about drugs for the treatment of mastopathy. From it you will learn about the symptoms of the disease, modern methods of treating mastopathy, the effectiveness of diet and taking vitamins, homeopathic and hormonal remedies.

Duphaston is a synthetic gestagen that is effective not only for the treatment of gynecological and obstetric pathologies, but also in the fight against mastopathy.

Regular courses of this drug help to significantly reduce lesions and stop the progression of the disease. But this medicine has its own contraindications and regimens for use.

Therefore, whether it is possible to take duphaston for mastopathy in a specific situation, it is better to check with your doctor, who will prescribe the most effective treatment.

Source: http://GrudInfo.ru/dyufaston-pri-mastopatii/

Is it possible to use Duphaston to treat mastopathy?

To treat benign pathology of the mammary glands, you need to use various medications prescribed by your doctor. Duphaston for mastopathy is optimally taken by women planning pregnancy. A drug containing the hormone progesterone helps create favorable conditions for conception and reduces the risk of proliferation in breast tissue.

 

Positive properties

Medicines containing progesterone perform 2 main tasks in the treatment of any form of mastopathy:

• antiestrogenic effect (reduction of elevated levels of estrogen hormones);
• elimination of deficiency of gestagen hormones.

One of the effective drugs used for monotherapy of FCM is Duphaston, which has the following positive properties:

• pain relief (elimination of heaviness and premenstrual chest pain);
• antiproliferation (prevention of the adverse effects of hyperestrogenism, manifested by hyperplasia of milk lobule cells);
• vasodilation (elimination of edema and improvement of blood supply to breast tissue);
• normalization of general hormonal levels with correction of ovarian function.

Considering the positive effects of the drug, the answer to the question whether Duphaston can be taken for mastopathy will be positive: the drug, often used by gynecologists, can be safely taken during FCM, especially at the stage of preconception preparation.

Indications for therapy

Not in all cases can Duphaston monotherapy be used for various forms of mastopathy. The main indications for use of the drug are:

• a combination of the diffuse variant of the disease and childbearing age (if a woman wants to become pregnant and give birth to a child);
• mastopathy with a fibrous or cystic component against the background of menstrual irregularities (shortened cycle, heavy periods, unsystematic arrival of menstruation);
• combined pathology of the uterus and mammary glands (leiomyoma, endometriosis);
• preconceptional preparation in women with any forms of hyperestrogenism, manifested through breast pathology or hyperplastic processes of the endometrium.

As doctors' reviews show, it is optimal to use a hormonal drug for monotherapy of diffuse forms of FCM in young women who dream of finding the happiness of motherhood, at the stage of preparation for pregnancy. In addition, Duphaston can be included in complex treatment regimens for menstruating women with various types of gynecological pathologies.

Contraindications for treatment

The doctor will prescribe any treatment option after a full examination and exclusion of dangerous types of breast pathology. Duphaston should not be used if the following diseases are detected:

• menopausal age in women;
• nodal variants of mastopathy;
• diffuse cystic type of pathology when a large cavity is detected;
• detection of precancerous cellular changes;
• malignant breast tumor.

 

It is important to strictly follow the advice of a mammologist, especially against the background of a hereditary predisposition to breast cancer or with a high risk of cancer.

Pregravid scheme

For monotherapy with Duphaston in women preparing for the desired conception and bearing a child, the following regimens are used:

• from 14 to 25 days of the menstrual cycle, 1 tablet 2 times a day;
• from 11 to 25 days of the cycle, 1 tablet daily.

The duration of course therapy can be 6 months. It is important to monitor the regularity of menstruation and the condition of the mammary glands. A good effect of monotherapy is the elimination of mastodynia and the onset of the desired pregnancy. If there is no positive effect, the doctor will suggest changing the therapeutic approach to the treatment of mastopathy.

Treatment technique

A possible option for including Duphaston in the treatment regimen of complex therapy is a long regimen - taking a tablet daily from the 5th to the 25th day of the menstrual cycle. In addition, you must take the following medications:

• vitamin and mineral complexes;
• sedatives;
• local transdermal hormonal ointments;
• decongestants and painkillers.

It is important to notice in time the complicated course of the disease, in which indications for surgical intervention arise.

Side effects

Duphaston, like any other hormonal drug, has side effects that can have a negative impact on a woman’s body. The main problems are associated with the negative effect on the liver when taking the medicine for a long time. Side effects when treated with the tablet form of Progesterone include:

• tendency to swelling;
• minor and transient pain in the right hypochondrium;
• problems with the digestive system (constipation, nausea, sometimes diarrhea);
• psycho-emotional changes (depression);
• headache;
• menstrual irregularities that occur through heavy periods;
• skin reactions (itching, rash).

Side problems can appear during a long treatment regimen, when a woman needs to take pills for almost the entire month. When using the preconception regimen, there are practically no complications.

Progesterone tablets are often used in young women with various forms of mastopathy, when it is necessary to solve 2 problems: get rid of benign breast pathology and create conditions for successful conception of the fetus.

Source: https://gynecologyhelp.ru/mastopatiya/dyufaston.html