Indomethacin: how to use rectal suppositories for prostatitis

Young people are increasingly suffering from prostatitis. In order to preserve men's health for a long time, you need to consult a doctor at the first signs of the disease and undergo a full course of treatment. Correctly selected drugs and their dosage affect not only the quality of current therapy, but also the patient’s entire future life.

Indomethacin suppositories belong to the group of non-steroidal anti-inflammatory drugs. The drug is aimed at quickly eliminating painful symptoms, but does not affect the causes of the disease. In the case of a bacterial or infectious nature of the disease, additional medications cannot be avoided. Therefore, the drug is not prescribed without preliminary testing.

Indomethacin effectively fights prostatitis in the acute and chronic stages. The popularity of the drug is due to its low cost, rapid effect and rare complications. The rectal method of administration allows you to reduce the load on the gastrointestinal tract and liver and speed up the delivery of drugs to the inflamed organ.

However, not everyone can use it due to the large number of contraindications and side effects of the drug, which we will discuss later in the article.

Indomethacin suppositories for prostatitis

Indomethacin suppositories got their name due to their main active ingredient – ​​a derivative of indoleacetic acid.

The main therapeutic property that the medication has is the elimination of inflammation, as well as the pain and heat that it causes.

The effect is achieved by stopping the synthesis of prostaglandin, which provokes a pathological phenomenon.

As a result of the effect of the drug, the volume of the prostate gland decreases (if we are talking about a chronic inflammatory process or benign hyperplasia).

Additional medicinal properties of Indomethacin suppositories:

• activation of blood circulation;
• strengthening the walls of blood vessels and small capillaries;
• prevention of blood clots;
• activation of metabolism;
• toning the walls of the colon.

Suppositories with indomethacin for prostatitis begin to work within half an hour after their administration, the drug reaches its maximum concentration in the blood after 2 hours. If you use them regularly, the focus of inflammation will gradually decrease and over time all the symptoms of prostatitis will disappear.

The manifestations of the disease pass quickly enough, but the course of treatment cannot end there. If the disease is not treated, a relapse may occur and the disease will enter the chronic stage. To speed up recovery and further maintain men's health, preventive measures are taken. Ultrasound therapy and prostate massage have a positive effect.

  Inexpensive and effective tablets for chronic prostatitis

The man quickly improves the process of urination, the stream becomes stable, without interruption, there is no pain, incontinence or urinary retention goes away. Intimate life gradually improves, libido increases and potency is restored. Premature ejaculation is eliminated and the duration of sexual intercourse increases.

Dosage and Application

Indomethacin is available in several forms: tablets, suppositories, gel. To treat inflammation of the prostate gland, it is advisable to use tablets and rectal suppositories.

For the treatment of prostatitis, 0.5-0.75 mg tablets are prescribed, that is, 2-3 tablets per day, with a dosage of 0.25 mg. In the absence or weak dynamics, the dosage can be increased to 200 mg per day.

One suppository is placed at night; for severe symptoms, 2 suppositories can be placed per day, with a dosage of 0.5-1 mg. The maximum daily dose is 150 mg. Otherwise, an overdose and side effects may occur.

After the first dose, the patient should monitor all sensations that arise. In case of individual intolerance to indoleacetic acid, Indomethacin is stopped and another drug is prescribed.

Before using a rectal suppository, you must first cleanse the intestines. This can be done naturally or with an enema.

The advantage of suppositories, as opposed to tablets, is that the prostate gland is located in close proximity to the rectum, so medicinal substances quickly reach the source of inflammation. There is also no risk of toxicity for other internal organs.

Recommendations for the use of Indomethacin suppositories:

• use 1 10 mg suppository once a day, or 2 50 mg suppositories at different times of the day;
• a comfortable position for inserting a suppository - lying on your side with your knees pulled up to your chest;
• It is better to administer the suppository before bedtime or during rest, having the opportunity to lie down for a while;
• the candle is inserted with a finger, a glove is put on the hand;
• to reduce discomfort, the finger is lubricated with fat or petroleum jelly;
• After administration, you must remain in a lying position for at least 30 minutes.

The duration of treatment for prostatitis with suppositories is 7 days. If there is a need to extend the course of treatment, the drug is replaced. Long-term use of Indomethacin leads to side effects.

Most of the active substance is excreted through urine, the rest through feces.

Indications for use

Indomethacin suppositories are used to treat the following pathologies:

• any inflammatory processes in the body, including the prostate gland;
• rheumatism;
• arthritis;
• phlebeurysm;
• hematomas;
• ulcers;
• pathologies of the respiratory organs of an infectious nature;
• pain in the spine;
• neuralgia;

Suppositories are also used to treat female diseases, namely:

• endometriosis or uterine fibroids;
• pain during the menstrual cycle;
• inflammatory phenomena.

Reviews from men confirm that these suppositories for prostatitis in men are among the most effective. Doctors also often prescribe Idomethacin, as they have a broad spectrum of action and are suitable for many patients.

  The influence of alcohol on the development of prostatitis in men

When treating prostatitis, suppositories help eliminate the following symptoms:

• inflammatory process;
• swelling;
• pain in the perineum;
• increased local temperature;
• urinary disturbance.

Intomethacin is more suitable for mild forms of prostatitis or for treating it at a chronic stage. During an exacerbation, the presence of high body temperature and severe pain, it is necessary to take a whole range of drugs, depending on the test results; antibacterial, antiviral or antifungal drugs may be required.

The drug is used only against prostatitis, it is not used for adenoma or prostate cancer.

Contraindications

Indomethacin suppositories for prostatitis have a number of contraindications. Before prescribing them, the doctor must take tests from the patient and study his medical card. With a one-time use of the suppository, it will not have a negative effect on the body, but if its systematic use is planned, then some diseases will be excluded.

Contraindications to the use of the drug:

• age under 18 years;
• use of other NSAIDs;
• high blood pressure;
• impaired liver and kidney function;
• viral hepatitis;
• hemophilia;
• acute pyelonephritis, glomerulonephritis;
• bronchial asthma;
• internal bleeding;
• stomach or duodenal ulcer;
• colitis, enterocolitis;
• pathology of the optic nerve;
• epilepsy.

Also, suppositories should not be used if the patient suffers from hemorrhoids or has purulent inflammation of the rectum. Although suppositories can relieve inflammation, in this case they will do harm. Indomethacin affects the process of platelet adhesion, slowing it down, which can lead to bleeding from hemorrhoids or other open wounds.

The immune response is reduced by blocking the production of arachidonic acid. Therefore, Indomethacin is not prescribed in debilitated states of the patient and in cases of immunodeficiency.

An allergic reaction to the components included in Indomethacin may occur, or intolerance to any NSAID drugs may occur, in which case the treatment regimen is revised.

Strict medical supervision is required when treating patients over 65 years of age, as well as with heart failure and Parkinson's disease.

Side effects

In case of incorrect prescription, self-treatment or overdose, pronounced side effects are possible. If you experience discomfort after using suppositories, you should stop therapy and consult a doctor.

During the treatment process, it is necessary to monitor not only the dynamics of the prostate gland, but also the general condition of the body. Throughout the duration of taking the drug, it is necessary to take urine and blood tests, monitor the condition of the liver and kidneys.

What side effects may a patient encounter when using Indomethacin suppositories for prostatitis:

• stool disorders, bloating, nausea, bleeding and perforation (formation of a through hole) in the gastrointestinal tract;
• dizziness, migraine, sleep disturbance, anxiety, irritability, overexcitation of the nervous system;
• hypertension;
• liver and kidney failure;
• necrosis of kidney tissue, hematuria, blood in the urine;
• swelling, bronchospasm, anaphylactic shock, redness of the skin;
• inflammation of blood vessels in the skin and subcutaneous fat;
• convulsions, decreased levels of leukocytes and platelets in the blood, anemia.

  Treatment and prevention of prostatitis with tablets

The first part of the list of side effects happens more often. The longer you take Indomethacin for prostatitis, the more dangerous the overdose symptoms become.

Indomecin for prostatitis is rarely used as the main remedy for the treatment of prostatitis; more often it is additional. If it is ineffective or side effects occur, the drug is replaced with one that is more suitable for the patient and safer.

Despite its effectiveness, patients also note the downside of Indometacion treatment. During or after treatment, irritation, itching, dryness, and discomfort appear in the anus. Most often this happens with long-term therapy or high dosage.

Interaction with other drugs

At the moment, no studies have been conducted on the interaction of Indomethacin with other drugs. However, there is a list of drugs with which it is not recommended to combine the medication.

An undesirable reaction may be caused by taking Indomethacin with anticoagulants, since the risk of bleeding increases and the blood thinning effect increases. When taken simultaneously with diuretics, their diuretic properties will decrease. If you take NSAIDs and glucocorticoids, then the likelihood of developing side effects from the latter increases.

During treatment you should avoid drinking alcohol.

Analogs

Non-steroidal anti-inflammatory drugs are prescribed if antibiotics are powerless in combating the source of inflammation. In case of long-term use of the latter and their negative effect on the body, they are replaced with alpha-blockers.

Speaking about analogues of Indomethacin by drug group and active substance, the following are distinguished:

• Indotard;
• Indocollier;
• Elmetacin;
• Methindol;
• Indovis EU;
• Indobene;
• Tridocin.

Analogs are also available in various forms: tablets, ointments, suppositories. But each drug has a different dosage and dosage regimen, since the amount of the active substance and the list of additional components are different. Before using suppositories, be sure to read the instructions for use.

If the above medications cannot be used for treatment, then they are replaced with other NSAIDs:

• Diclofenac;
• Naproxen;
• Ibuprofen;
• Nimesulide;
• Piroxicam;
• Ketorolac.

Without consulting a doctor, it is forbidden to replace the drug yourself, as this can lead to negative consequences.

Source: https://prostatitoff.com/prostatit/pomogayut-li-svechi-indometacin-pri-prostatite.html

Indamethacin suppositories for prostatitis: reviews and instructions for use

• Urologist-andrologist 1st category Petr Viktorovich
• 46058
• Update date: December 2019

Indomethacin rectal suppositories are prescribed for prostatitis.

This is a drug that belongs to the group of non-steroidal anti-inflammatory drugs. It relieves the symptoms of the disease, after which the man feels relief.

The suppositories contain substances that suppress the activity of the inflammatory process.

Composition and pharmacological properties

The drug relieves pain symptoms in the prostate well

Indomethacin effectively fights inflammatory processes in the prostate gland. This drug has a traditional form for candles, which in appearance resembles a torpedo. The surface of the candles is smooth. They are painted white or yellowish. The drug has no odor.

The main component of suppositories is the substance indomethacin. It is supplemented with paraffin and fat. Thanks to them, suppositories have the correct shape. The medication may also contain other components.

Their presence in the composition directly depends on the company that manufactures the drug. Manufacturers often add lavender oil, alcohols, vitamin-mineral complexes and starch.

These substances enhance the effect of the drug and improve the process of absorption of the active component by the body.

The action of the active substance Indomethacin is primarily aimed at suppressing the work of enzymes that lead to the production of prostaglandins. These components are mediators of the inflammatory process.

Suppositories prevent platelets from sticking together, and they also block the release of pyrogens. They have a ganglion-blocking effect. The drug successfully normalizes the body's production of norepinephrine and adrenaline.

Indomethacin for prostatitis performs several important tasks:

1. Relieves inflammation in the genitourinary system.
2. Anesthetizes the affected area.
3. Reduces elevated temperature.

Due to these properties, the drug as part of complex therapy helps men get rid of prostatitis.

Treatment with Indomethacin

For inflammation of the prostate gland, it is recommended to use Indomethacin in the form of suppositories. This is the most suitable dosage form of the drug, which allows you to deliver the active substance directly to the lesion of the genitourinary system.

If the drug is administered rectally, 90% absorption of the active substance in the tissues of the inflamed prostate can be achieved. Due to this, an immediate analgesic and anti-inflammatory effect occurs.

The drug has the ability to be distributed throughout the male body. It is not difficult for him to overcome the blood-brain barrier and penetrate the synovial fluid.

Indications

Suppositories are recommended for problems with the prostate gland and other male diseases

A medication in the form of suppositories can be recommended for patients with the following diagnoses:

• benign prostatic hyperplasia;
• prostatitis;
• rheumatoid arthritis;
• neuralgia;
• gout;
• cystitis.

The use of suppositories allows you to influence inflammatory foci in any area of ​​the pelvis and lower back.

Contraindications

Indomethacin for prostatitis and other similar diseases is not indicated for every patient. People who have the following contraindications to it should refuse treatment with this drug:

1. Individual intolerance to the components of the drug.
2. Heart failure.
3. Kidney and liver failure.
4. Ulcers and erosions of the rectum.
5. Diseases of the gastrointestinal tract that are in the acute stage.
6. Diseases of the hematopoietic system.
7. Bronchial asthma.

For such diseases, it is recommended to refrain from using suppositories. It is better to choose a safer analogue that is characterized by a similar effect.

Side effects

After using the drug, nervousness and outbursts of anger may occur.

Using suppositories for prostatitis, men rarely encounter side effects. This is confirmed by patient reviews of the drug. The occurrence of negative reactions in most cases is due to improper use of the drug and non-compliance with its dosage.

It is difficult to avoid side effects for patients who are treated with Indomethacin for a long time.

Suppositories containing bendomethacin can cause disruption of the digestive tract. They can lead to nausea, diarrhea or constipation, and bloating. In particularly difficult situations, patients are diagnosed with bleeding and gastric perforation.

More common complications are allergic reactions. Patients who decide to use the drug are prone to them, despite the increased sensitivity of their body to its components.

This reaction is limited to bronchospasms, body rashes, anaphylactic shock and angioedema. These are dangerous conditions that, without timely help, can lead to death.

The side effects that result from the use of the Indomethacin suppository include other conditions:

1. Insomnia.
2. Irritability.
3. Anal fissures.
4. Thrombocytopenia.
5. Leukopenia.
6. Anemia.
7. Drowsiness.
8. Headache.
9. Haemorrhoids.

Compliance with the doctor’s instructions regarding the use of this drug helps to avoid side effects and complications after using the suppository. Suppositories can be introduced into a course of therapy (treated with Indomethacin) for prostatitis only after a complete diagnosis of the body. It will help ensure that there are no contraindications, which are the main reason for the development of unwanted reactions.

Instructions for use

Can be purchased at almost any pharmacy over the counter, without a prescription.

On sale you can find Indomethacin suppositories, in which the concentration of the active substance is 50 mg or 100 mg. The urologist himself decides what dosage the patient should choose to cope with prostatitis.

You should start administering medicinal suppositories only after cleansing the intestines. If necessary, you can use an enema. This preparation will allow the drug to reach the source of inflammation.

The dosage and duration of treatment with the drug directly depends on the disease that worries the patient:

1. Acute course of bacterial prostatitis. The patient needs to use suppositories 2 times a day. The dosage of each suppository should be 100 mg.
2. Chronic course of prostatitis. It is enough to put 50 mg suppositories 2 times a day. It is also possible to use only 1 suppository, but at a dosage of 100 mg.
3. BPH. It is necessary to insert suppositories at a dosage of 100 mg 2-3 times a day. The optimal number of procedures depends on the size of the adenoma.

It is almost impossible to achieve an overdose with rectal administration of Indomethacin. Such cases have not been officially recorded.

The patient must understand that suppositories are not able to completely cure the disease. Their main task is to suppress painful symptoms.

The drug can be used for a month 3-4 times a week. Afterwards it is necessary to replace it with another medication.

Drug interactions

To avoid complications, you need to carefully read the instructions for the medicine and talk to your doctor

Indomethacin for prostatitis can interact with the active components of other medications. Therefore, it is necessary to pay attention to this point if the patient needs to take different medications at the same time.

The doctor should take into account the following features:

• Combining suppositories with other non-steroidal anti-inflammatory drugs increases the likelihood of bleeding in the gastrointestinal tract.
• Taking antibiotics increases the risk of developing seizures and allergies.
• The combination of Indomethacin with anticoagulants and vasodilators leads to bleeding.

Incorrect combination of medications with the drug can lead to the development of dangerous complications. Therefore, the patient is prohibited from taking additional medications that have not been approved by his attending physician. These points must be discussed with him.

Price and analogues

You can buy Indomethacin suppositories in many pharmacies. Their cost varies between 150-400 rubles. The final price of the drug is influenced by the manufacturer who produces it.

As mentioned earlier, not all patients are suitable for therapy based on Indomethacin suppositories. In this case, the urologist must select the optimal analogue. The choice falls on a non-steroidal anti-inflammatory drug, which also copes with pain and swelling. The most effective drug substitutes are:

• Suppositories with ibuprofen;
• Suppositories with diclofenac.

If the patient experiences a strong burning sensation or notices an allergy after using Indomethacin, the doctor may recommend supplementing the suppositories with Analdim. This remedy combines analgin and diphenhydramine. You can take it for up to 3 days, 2 times a day.

Reviews

Alexey, 53 years old

The urologist recommended that I use suppositories after I complained of acute pain due to prostatitis. Indomethacin suppressed the attacks well. After about 2 hours the pain subsided. I use candles only when necessary, and not in courses. So far there has not been a single time when the drug did not work. Therefore, I can only speak positively about him.

Stepan, 60 years old

From personal experience I have seen how well suppositories with indomethacin help fight severe pain and swelling caused by acute prostatitis.

Although suppositories cannot completely stop the disease, they alleviate its symptoms very quickly. Now I always keep them in my home medicine cabinet so that during the next exacerbation I can save myself from severe pain in the lower abdomen.

Once after such therapy I developed itching. Fortunately, this adverse reaction did not recur.

Source: https://muzhik.guru/prostatit/lechenie/svechi-indometatsin-pri-prostatite/

"Indomethacin" for prostatitis: treatment with suppositories and reviews

Properly organized treatment of any disease using correctly selected medications almost always ensures a positive result.

Anti-inflammatory drugs are considered the “gold standard” in the treatment of prostate inflammation. They are prescribed in combination with antibiotics to eliminate symptoms and alleviate the patient's condition.

The group of non-steroidal drugs includes Indomethacin, which has a pronounced effect.

"Indomethacin": main characteristics

The drug belongs to the group of non-steroidal drugs that not only stop the pathological process, but also fight other characteristic manifestations: pain, fever, tissue swelling.

Form, composition, properties

• rectal suppositories 25, 50 or 100 mg, 6 pcs. packaged;
• ointment for external use 10% – tube 40 g;
• enteric-coated tablets 25 mg – 30 pcs.

Dosage form Active substance Auxiliary components

Pills	indomethacin	Magnesium stearate, lactose monohydrate, MCC, potato starch
Gel	indomethacin	Sodium benzoate, carbomer, propylene glycol, ethanol, macrogol
Ointment
Candles

Rectal suppositories of a yellowish-white color have a convenient torpedo-shaped shape, which ensures comfort and painlessness during administration. They are affordable and available with a doctor's prescription.

Range of applications

As reviews show, the medication has a wide spectrum of action and is indicated for internal and external use. It helps to effectively relieve inflammation in the following cases:

• pathologies of the musculoskeletal system;
• soft tissue injury;
• infectious diseases of ENT organs;
• diseases of the female genital area;
• dysfunction of the male genitourinary system;
• problems related to ophthalmology.

"Indomethacin" for prostatitis

Against the background of the inflammatory process with prostatitis, swelling of the gland tissue, an increase in its size, as well as the appearance of redness (hyperemia), itching and pain are observed.

This is due to the action of physiologically active elements - prostaglandins, which increase the sensitivity of some receptors to pain mediators - histamine and bradykinin.

The mechanism of action of Indomethacin is to slow down enzymatic processes, resulting in a decrease in the production of these substances.

The drug is available in various forms, but for the treatment of prostatitis it is advisable to use rectal suppositories. Thanks to this introduction, the active substance, while maintaining a high concentration, quickly reaches the site of inflammation and has a local effect.

Often suppositories are used due to some restrictions on taking the medication in other forms. One of them is stomach diseases. The active ingredient in the form of suppositories reaches its goal without irritating the digestive system and without irritating its mucous membrane.

Expected effect

In complex therapy of inflammation, suppositories with indomethacin for prostatitis are used for local symptomatic treatment. As indicated in the instructions for use, the drug has antipyretic, anti-inflammatory, and analgesic effects. Due to this, it has a complex pharmacological effect:

1. Relieves pain, which leads to rapid relief of the general condition.
2. Relieves inflammation and swelling of tissues, as a result of which the process of urination is normalized.

The product activates blood circulation in the pelvis, which improves venous outflow, reduces the risk of blood clots and prevents stagnation of prostate secretions.

Indications

Despite the significant range of therapeutic effects, the drug is indispensable for inflammatory processes occurring specifically in the prostate gland.

It is prescribed for acute or chronic disease, adenoma, as well as for severe congestion in the tissues of the male organ.

Urologists often prescribe Indomethacin suppositories for prostatitis of a bacterial or infectious nature, as well as for a complicated form of the disease - calculous (with the formation of salt stones) or purulent.

Possible side effects

Regardless of the form of release, the drug can sometimes cause a number of side effects from various body systems.

1. Digestion. Nausea, vomiting, bowel movements, anorexia.
2. Heart and blood vessels. Persistent changes in blood pressure, tachycardia, arrhythmia, palpitation, edema, hematuria.
3. Peripheral and central nervous system. dizziness, pain, anxiety or, conversely, depressive states, muscle weakness, nephropathy, mental disorders, sleep disorders.
4. Sense organs. Impaired visual or auditory perception, pain and double vision, ringing in the ears.
5. In some cases, disorders of the hematopoietic system may be observed, as well as renal or liver failure, allergic reactions of various etiologies - dermatitis, bronchial asthma, Quincke's edema.

Treatment regimen

The doctor prescribes rectal suppositories as an adjuvant in the combined treatment of prostatitis. The active component indomethacin, like ichthyol, quickly penetrates tissue cells and begins its complex action.

To achieve a quick effect, candles are recommended to be used regularly. The most favorable time is the morning after waking up and the evening hours shortly before bedtime. The doctor draws up the application regimen individually, taking into account the complexity of the clinical case and the patient’s age.

Adults and elderly patients. Depending on the concentration of the drug, administration of one suppository is indicated 1 or 2 times a day.

Boys over 14 years old. One dose of 1 suppository containing 50 mg of active ingredient.

If side effects occur, you should consult your doctor. He may reduce the dosage by half or advise you to switch to taking any analogue. The drug should be injected deep into the rectum, then lie on your stomach for 30 minutes.

Contraindications

As with most medicines, there are a number of clear contraindications for Indomethacin.

1. Hypersensitivity to the components of the drug.
2. Functional disorders of the kidneys and liver.
3. Ulcerative lesions of the digestive system.
4. Disturbances of hematopoietic processes.
5. Arterial hypertension in severe form.
6. Severe heart diseases.
7. Parkinson's disease.
8. Epilepsy, seizures of unknown etiology.
9. Severe inflammatory pathologies of the pancreas.
10. Pregnancy and lactation period.
11. Children under 14 years of age.

Overdose

If the specified daily volume of the drug was exceeded, no symptoms of overdose were identified. This indicates the safety of the drug.

special instructions

Doctors advise using indomethacin suppositories with extreme caution for elderly people. They also recommend monitoring changes in the peripheral blood picture by analyzing it. It is necessary to carefully monitor liver and kidney functions.

When using suppositories or other forms of medication, concentration and speed of psychomotor reactions may decrease. Therefore, doctors advise refraining from hazardous activities associated with these indicators.

Interaction with other drugs

Based on many years of research and extensive practice, the medication has shown good interaction with drugs used in combination therapy for prostatitis. However, you need to be especially careful when choosing non-core drugs, which in combination with Indomethacin can cause various unpredictable consequences.

Experts advise against using Indomethacin simultaneously with certain other medications.

1. With Probenecid, as it helps to increase the amount of indomethacin in the blood plasma.
2. With acetylsalicylic acid and diflunisal, since it can provoke the development of bleeding from the gastrointestinal tract.
3. With Digoxin, since there is an increase in the concentration of the latter.
4. With other representatives of the NSAID group, as the toxicity of cyclosporine increases.
5. With lithium preparations, since the latter can accumulate in the blood plasma and be slowly eliminated in persons suffering from mental disorders.

Replacement therapy

Some other drugs, so-called analogues, are no less effective in treating inflammatory diseases. These include:

• "Metindol";
• "Indobene";
• "Diclofenac";
• "Ibuprofen";
• "Butadion".

Ichthyol suppositories have proven themselves well for prostatitis. The main active ingredient is ichthammol. Just like indomethacin suppositories, they should be administered rectally deep inside, after emptying the intestines naturally or with an enema.

Ichthyol suppositories have a whole range of healing effects:

• relieve inflammation;
• promote cell regeneration;
• inhibit the activity of pathogens;
• relieve tissue swelling;
• eliminate pain;
• normalize urination.

Reviews about taking Indomethacin for prostatitis

Reviews about indomethacin suppositories for any prostatitis are quite contradictory. Some managed to get rid of the disease, but at the same time received new sores in the form of a rash, small wounds and irritations of the mucous membrane.

Others, on the contrary, not feeling any improvement, started taking pills and experienced “all the delights” of side effects.

One way or another, there were much more positive reviews about the effectiveness of the drug than negative ones.

Vladislav, 39 years old

Sergey, 45 years old

I was diagnosed with chronic prostatitis. At first I didn’t even suspect its existence, but when pain and problems with urination appeared, I consulted a doctor. He will prescribe me a course of therapy, including rectal suppositories. Having figured out how to use them, I returned home and began treatment that same day.

I felt the effect on the same day, but time after time I began to notice that for about half an hour after administration I felt a burning sensation and discomfort. After reading the instructions, I realized that this was one of the side effects and calmed down. Now, at the slightest pain, I try to use suppositories with indomethacin.

Source: https://UroMir.ru/vospalenie/medicamenty/indometacin-pri-prostatite.html

Indomethacin suppositories for prostatitis

Indomethacin is a drug that is often prescribed for infectious and inflammatory diseases, to relieve pain and relieve discomfort, including inflammation of the prostate. However, before using Indomethacin suppositories for prostatitis, you need to read the instructions for their use, side effects and contraindications.

Description of indomethacin

This compound belongs to the class of NSAIDs (non-steroidal anti-inflammatory drugs). Indomethacin is a derivative of indoleacetic acid and has anti-inflammatory, antipyretic, decongestant, antiplatelet and analgesic properties. The drug can:

• reduce the inflammatory process,
• reduce pain symptoms,
• prevent the formation of blood clots,
• reduce temperature
• activate metabolism,
• relieve swelling,
• reduce congestion in prostate tissues.

The main types of action are analgesic and anti-inflammatory. The mechanism of action of indomethacin is based on blocking the action of inflammatory mediators - prostaglandins, which increase the sensitivity of nerve receptors to pain mediators - histamine and bradykinin.

The drug reduces the production of arachidonic acid and reduces the immune response. At the same time, the production of pyrogens is blocked and platelet activity decreases.

The use of indomethacin suppositories alleviates the general condition of a patient with prostatitis and the process of urination, which can be difficult due to the enlargement of the prostate gland.

Indomethacin suppositories are prescribed for bacterial (chronic and acute), calculous and congestive prostatitis (chronic pelvic pain syndrome). In this case, prostatitis must have obvious symptoms of inflammation: pain, burning, discomfort.

Why is it best to use suppositories for prostatitis?

Prostatitis is inflammation of the prostate gland. Usually the disease is accompanied by serious pain, and the gland itself swells greatly.

Local forms of drugs are preferable, since the medicinal substances from their composition penetrate directly into the site of inflammation. The bioavailability of indomethacin when administered rectally is 90%.

The maximum concentration of indomethacin in the blood when applied topically is achieved after 2 hours.

Anti-inflammatory drugs have only a symptomatic effect. If prostatitis is caused by pathogenic bacteria, then therapy is unthinkable without antibacterial drugs. Prostatitis also requires the use of other types of drugs - antispasmodics, alpha-blockers. In addition, the doctor may prescribe (in the absence of contraindications) tablets with indomethacin.

Indomethacin suppositories are an effective treatment for prostatitis, but you should not self-medicate with them. After all, pain and discomfort are often caused not by prostatitis, but by other diseases.

It is necessary to see a doctor and undergo the entire course of examination (ultrasound, analysis of prostate secretions) so that he can diagnose “prostatitis” and exclude serious diseases, such as malignant tumors.

Only after a diagnosis has been established can treatment with indomethacin suppositories begin.

Rectal suppositories with indomethacin

Rectal suppositories contain some amount of indomethacin, but they are based on solid fats. The composition of auxiliary components may vary depending on the manufacturer of the drug.

Manufacturers can add starch, lavender oil, silicon dioxide, urea, castor oil, and petroleum jelly to the composition of candles.

In Russian pharmacies you can find candles produced by the companies Berlin-Chemie, Sopharma, Biosintez, Altfarm.

Fat also softens the surface of the intestinal mucosa and makes it susceptible to the effects of indomethacin. Corn starch has a protective effect on the mucous membrane.

After the candle dissolves, the starch decomposes into glucose, which saturates the tissues with energy.

The rectum is very close to the prostate gland, so the active substance, absorbed into the mucous membrane of the rectum, very quickly ends up in the prostate. After 15 minutes, a man can already feel a reduction in pain.

If the patient experiences an increase in temperature, then this symptom of prostatitis also goes away. The patient's general condition improves. However, one use of a suppository is usually not enough to achieve a lasting effect.

With constant use, the drug accumulates in the prostate gland, which leads to a stable therapeutic effect. The active component is excreted mainly in urine, partly in feces.

The dosage of indomethacin in suppositories can be 50 and 100 mg. White-yellow suppositories are torpedo-shaped, which ensures painless administration.

Indomethacin suppositories are distinguished from other similar drugs by their affordable price. On average, a package costs 100 rubles. Suppositories should be stored for no more than 3 years at a temperature not exceeding +25С. This condition is important, because at a temperature close to the temperature of the human body, the suppositories will begin to melt and lose their shape.

Suppositories with indomethacin are sold in pharmacies without a doctor's prescription.

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Reviews from patients and doctors who treated prostatitis with indomethacin suppositories are mostly positive. The popularity of the drug is due to its main qualities:

• low price,
• high efficiency,
• quick action
• relative safety.

Suppositories show high effectiveness in chronic prostatitis and during exacerbations of the disease. Sometimes patients complain of a burning sensation after the administration of suppositories, which quickly passes.

Contraindications

It is not recommended to use suppositories with indomethacin:

• children under 14 years of age;
• elderly patients (over 80 years old);
• people with serious gastrointestinal diseases (stomach and duodenal ulcers, ulcerative colitis, gastritis, bleeding from the stomach and intestines);
• patients suffering from bronchial asthma;
• with severe heart failure;
• with liver and kidney failure;
• those suffering from epilepsy;
• with severe hypertension;
• with immune deficiency;
• with severe exhaustion.

The use of indomethacin suppositories for diseases of the anus and intestines is prohibited:

• damage to the rectum,
• hemorrhoids,
• colitis,
• anal fissures,
• proctitis.

In these cases, the drug may cause bleeding from the colon or hemorrhoids.

The medicine is not used for:

• individual intolerance to indomethacin,
• hypersensitivity to any NSAIDs,
• concomitant use of other NSAIDs,
• bleeding disorders,
• internal bleeding.

special instructions

Treatment of patients over 65 years of age, people suffering from heart failure, Parkinson's disease is carried out under strict medical supervision.

During the treatment of prostatitis, it is recommended to monitor the condition of the gland, blood and kidneys, and the general condition of the patient.

The drug should be prescribed with caution to people engaged in work that requires coordination and great concentration. Men using suppositories with indomethacin for a long time should refrain from driving.

During therapy you should avoid drinking alcohol.

Side effects

Side effects are rare with the rectal form of indomethacin. But they cannot be excluded. Typically, side effects occur with long-term use of the drug or if the patient exceeds the dosage specified in the instructions. To reduce the likelihood of side effects, it is necessary to use the drug in minimal doses and for the shortest possible course (7 days).

Patients often complain of itching and burning in the anal area immediately after insertion of the suppository.

Of the systemic side effects, the patient most often encounters gastrointestinal disorders:

• constipation,
• diarrhea,
• nausea and vomiting,
• flatulence,
• decreased appetite.

Very rarely may occur:

• perforation of the gastrointestinal tract and bleeding from the gastrointestinal tract;
• dizziness;
• decreased visual and hearing acuity;
• changes in the number of leukocytes and platelets in the blood;
• aplastic or hemolytic anemia;
• convulsions;
• hypertension or hypotension;
• liver and kidney failure, toxic hepatitis;
• hair loss;
• arrhythmia, tachycardia.

Systemic and skin allergic reactions can occur extremely rarely:

• Quincke's edema,
• bronchospasm,
• anaphylactic shock,
• hives,
• itching,
• allergic dermatitis.

With long-term use of the drug, the following may occur:

• headaches,
• excitement,
• anxiety,
• sleep disorders,
• chronic fatigue,
• irritability.

There have been no cases of overdose of indomethacin when administered rectally. However, you should not exceed the dosage indicated in the instructions.

Interaction with other drugs

Beta-blockers reduce their effectiveness when used simultaneously with indomethacin; indirect anticoagulants, on the contrary, increase their effectiveness.

It is undesirable to use indomethacin suppositories simultaneously with taking other NSAIDs, as this increases the risk of bleeding in the gastrointestinal tract. Use simultaneously with antibiotics increases the risk of allergic reactions and seizures.

When used simultaneously with indomethacin, glucocorticosteroids increase the risk of developing their side effects.

The use of suppositories with indomethacin for prostatitis

Before using indomethacin suppositories for the treatment of prostatitis, you should consult your doctor, as this drug has a number of contraindications. Your doctor can tell you the preferred frequency of use and dosage.

Before using suppositories, it is recommended to cleanse the intestines, and it is also advisable to use an enema. This will ensure rapid absorption of the medicine into the local bloodstream. Before the procedure, you should wash your hands (or carry out it with gloves).

It is better to moisten the candle in water, and lubricate the anus with baby cream or Vaseline. Then you should lie on your left side and press your legs to your chest. Suppositories must be inserted using a finger to a depth of approximately 2.5 cm. After insertion, you should remain in a supine position for about half an hour so that the suppository has time to dissolve unhindered.

The best time to administer indomethacin suppositories is the morning immediately after waking up and the evening (shortly before bed).

For chronic prostatitis, 1 suppository of 100 mg or 2 suppositories of 50 mg per day is administered. For acute bacterial inflammation of the prostate, 2 suppositories of 100 mg per day may be required. It is not recommended to exceed the daily dosage of 200 mg. Otherwise, the likelihood of side effects increases sharply. Do not use the drug more than 2 times a day.

The course of treatment for prostatitis can last several weeks (usually 10-14 days, sometimes up to 28 days). Often the doctor prescribes 2 suppositories to be administered in the first week, and in the second week, if the symptoms subside, he reduces the number of suppositories to 1. However, it also happens that the remedy does not work. Then the doctor either increases the dose or discontinues indomethacin and switches to another drug.

Suppositories begin to act very quickly, after the first administration. However, under no circumstances should you stop the course of treatment prescribed by your doctor.

The drug should not be used to treat children under 14 years of age.

After the first use, the patient must carefully monitor his condition. If side effects occur, you should consult a doctor. He will reduce the dosage or recommend a similar drug as a replacement. Most often, analogs with diclofenac and ibuprofen are used as a replacement for indomethacin suppositories.

During the treatment of prostatitis, the patient should avoid:

• drinking alcohol and spicy foods,
• hypothermia,
• excessive physical activity.

All this can reduce the therapeutic effect to zero.

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Source: https://lechim-prostatit.info/lekarstva/svechi/indometacinovye-svechi-pri-prostatite/