Alpha adrenergic blockers: popular drugs for prostatitis

With the help of alpha-blockers, urinary disorders are eliminated, pain is relieved and potency increases. Drugs in this group are not the basis of treatment, however, they are increasingly prescribed for chronic prostatitis and prostate adenoma. The course of therapy is long and ranges from 4 to 8 weeks.

Drugs used to treat prostatitis

Medicines used to treat prostatitis:

1. Alpha adrenergic blockers. The drugs are aimed at improving urination. After their use, tension is relieved from the bladder, which is compressed by the enlarged prostate.
2. Antibiotics. If bacteriological prostatitis is diagnosed, drugs are prescribed to suppress the development of pathogenic microorganisms. Rectal suppositories and injections are used.
3. NSAIDs. Prescribed to prevent the development of pathology and relieve the inflammatory process. The product helps relieve pain and discomfort during urination.
4. Antispasmodics. With their help, spasm of the muscles of the prostate and bladder is relieved. A man can go to the toilet and have sex painlessly, and the outflow of prostate juice is also facilitated.
5. Hormonal drugs. Prescribed to normalize hormonal levels, improve blood circulation, and eliminate swelling.
6. Phytotherapeutic drugs. This group of medicines is based on herbal components. Their action is less aggressive and is aimed at eliminating swelling and inflammation, alleviating pain and preventing the spread of pathology.
7. Vitamin complexes. Prescribed to improve local immunity and normalize metabolic processes.
8. Muscle relaxants. With their help, the outflow of prostate secretions improves and the tension in the bladder walls decreases.

Treatment of prostatitis should be comprehensive, but this does not mean that it is necessary to take all medications at once. Physical therapy and physiotherapeutic procedures are added to drug therapy. Additionally, it is necessary to exclude harmful products.

General understanding of alpha blockers

Alpha blockers are second-line drugs for the treatment of prostatitis. They are prescribed as an addition to antibiotics, anti-inflammatory and painkillers. This group of drugs is used to eliminate pain during urination and reduce inflammation.

Adrenergic blockers reduce or stop the production of adrenaline and norepinephrine, neutralizing the receptors that are responsible for them. After taking the drugs, the following effect is observed:

• elimination of muscle tone of the prostate and bladder;
• dilation of blood vessels and improvement of blood circulation;
• decreased blood pressure;
• decrease in blood sugar levels.

The drugs are also used to treat cardiovascular diseases. With chronic prostatitis, more than 50% of patients experience a positive effect on the 5th day of the course of therapy.

In case of prostate adenoma, these drugs help to avoid surgical intervention. A decrease in the tumor is observed already in the 2nd week of treatment, and the symptoms of the disease disappear after the first dose of the drug.

Types of drugs and purposes of use

There is a certain classification of alpha-blockers. The doctor prescribes the drug depending on the form of the pathology and the general health of the patient.

1. Non-selective. Prescribed for the chronic form of the disease, when the symptoms are not so pronounced, and during the period of remission there is practically no discomfort. These drugs have a stronger effect on the bladder muscles and nervous system, causing a number of side effects.
2. Selective. To quickly eliminate swelling and pain, take this type of adrenergic blockers. They are divided into short- and long-acting drugs. For chronic prostatitis, the latter are most effective. However, their use can cause retrograde ejaculation, when sexual intercourse does not end with ejaculation.
3. Uroslectic. The drugs eliminate muscle tone of prostate tissue and normalize sphincter function. Prescribed for long-term use. The effect is observed only after two weeks of therapy.

The drugs under consideration are aimed at improving urination, eliminating pain and urine retention, and preventing reflux. To increase potency, reduce headaches and dilate blood vessels in the brain, adrenolytics of another group are prescribed: beta-blockers.

The effect of drugs in this group on inflammation of the prostate

Alpha blockers act on the bladder and urethra, reducing swelling of the prostate. Depending on which enzyme is blocked, there are two classes that differ in their mechanism of action:

1. 5-alpha reductase inhibitors. The production of the hormone dihydrotestosterone in the male body decreases , which affects the pathological enlargement of the prostate. The active components of the drug gradually accumulate, so this therapy can last up to six months. Blockers of this class can affect potency and sperm production.
2. Alpha-1 adrenergic blockers. The drug blocks the spread of the inflammatory process in the prostate gland and on the mucous membranes of the bladder. Their effect begins within a couple of days after the start of administration. Not prescribed for infectious prostatitis, as well as for severe forms of pathology. No side effects from therapy were found in 90% of men.

In severe forms of prostatitis, inhibitors are prescribed. During treatment, you should not take drugs that enhance potency.

List of the most commonly used drugs, features of use

Alpha blockers are prescribed for prostatitis depending on the symptoms. There are many varieties that have different compositions of active substances.

An important factor in choosing a medicine is possible allergic reactions, arterial hypotension, liver disease or individual intolerance to any element. Below is a list of the most effective and popular drugs in this group.

"Tramsulosin"

This drug is most often prescribed for chronic prostatitis and adenoma, which are accompanied by urinary disorders. Tamsulosin selectively acts on the muscle muscles of the prostate gland and eliminates tone. It also stops the inflammatory process and has a positive effect on the bladder and urethra.

It is taken one capsule in the morning, after 7-8 hours the highest concentration of active substances is achieved. Elimination of painful symptoms and improvement in the patient’s health occurs after 7-10 days.

Tamsulosin may cause the following side effects:

• indigestion;
• defecation disorder;
• ejaculation disorder: its complete absence;
• allergic reaction.

The most popular analogue of this drug is “Omnik”; they contain identical components. Regardless of the name and price, the effect of use is the same.

"Terazosin"

This drug is based on the substance terazosin, which selectively affects the organs of the genitourinary system. Its use can reduce swelling, dilate blood vessels and improve blood circulation in the prostate gland, which promotes a speedy recovery. It is prescribed not only for inflammation, but also for the presence of benign neoplasms.

The dosage form of the drug is tablets containing 1, 2, 5, 10 mg of terazosin. The minimum treatment period is a month, during which the dose is gradually increased. Initially, it is recommended to take 0.5-1 mg before bed, by the end of the course it is possible to increase to 20 mg.

Side effects from therapy:

• lowering blood pressure;
• rapid pulse;
• fluid retention in the body;
• nausea and headache.

Terazosin is not prescribed with beta blockers, potency-enhancing drugs, or inhibitors. Self-prescribing and determining the dosage may not only not bring the desired effect, but also harm your health.

"Alfuzosin"

Alfuzosin belongs to the group of non-selective drugs. However, it is no less popular than other alpha blockers. It is prescribed for prostatitis, adenoma, and other urological diseases that lead to impaired urinary function. During use, the pressure in the prostate gland decreases, its swelling decreases, relieving the bladder from the load.

The dosage form is tablets that are coated with a yellow or white coating, each containing 2 or 5 ml of alfuzosin hydrochloride. It is taken several times a day, the maximum daily dose is 10 mg. The course of treatment is from 4 to 6 weeks.

The following side effects occur in rare cases (their occurrence may be due to overdose):

• low blood pressure;
• signs of poisoning, dry mouth;
• weakness, dizziness;
• tachycardia.

The simultaneous use of adrenergic blockers of different groups is prohibited. There is no effectiveness from such treatment, since the components of different drugs neutralize their effect on the body.

"Doxazosin"

The dosage form is tablets or capsules with white powder, each containing from 1 to 8 ml of the active substance. On average, treatment lasts 6 weeks, during which the dose of the drug is gradually increased every 7 days.

In case of overdose, side effects similar to other adrenergic blockers are observed: nausea, vomiting, absent-mindedness, weakness. Swelling of the face may occur due to the development of rhinitis. In extreme cases, the sphincter and bladder muscles lose tone, leading to urinary incontinence.

Doxazosin is recommended to be combined with 5-alpha reductase inhibitors. The treatment will be more effective, and the pathological symptoms will be eliminated on the third or fourth day.

Reviews about the treatment

“As soon as I was diagnosed with chronic prostatitis, the doctor prescribed many medications, including an adrenergic blocker. I took Tramsulosin during exacerbations for about 2 years.

A very effective remedy, it began to help over time after the first day of therapy. However, now it has stopped working.

The urologist said that the body was used to it and did not react to the active substances, so he prescribed Terazosin.

“On the doctor’s recommendation, I take Omnik. I feel much better: pain and burning have disappeared, potency has returned. However, sperm production has noticeably decreased. I’m not worried, because I read reviews from other men on the Internet that this is a temporary phenomenon. For the next course I plan to buy Tramsulosin, since its price is half as much.”

“I was told to definitely increase physical activity, otherwise there would be no effect from drug therapy. However, during the attacks I had difficulty getting up just to go to the toilet. After using Doxazosin for two weeks, I began to walk more in the fresh air. And at the end of the course I can run in the morning.”

“Alpha-blockers are drugs that help with prostatitis. During the 5 years of my illness, I alternated between taking Terazosin and Alfuzosin. Both worked for me: they did not cause any side effects and restored my sex life.”

Alpha blockers do not treat prostatitis. They are part of mandatory therapy for chronic forms, when urinary function is impaired. The drugs are safe and cause side effects only in 10% of cases. However, it is not recommended to prescribe the dosage yourself and combine them with means to increase potency.

Source: https://UroMir.ru/vospalenie/medicamenty/alfa-adrenoblokatory-preparaty-pri-prostatite.html

Alpha-blockers for prostatitis

Alpha adrenergic blockers are drugs that can slow down nerve impulses passing through the adrenergic synapse. Their action is based on temporary blocking of adrenergic receptors (alpha-1 and alpha-2). This property is used in cardiology (to reduce blood pressure in blood vessels) and urology.

The use of drugs such as alpha adrenergic blockers for prostatitis allows you to restore urination, impaired due to inflammation of the prostate.

What are alpha blockers used for?

The nervous system is directly related to the functioning of human organs and muscle control. When a person is healthy, this mechanism does not fail. However, with prostatitis, inflammatory processes negatively affect the functioning of the nervous system. This is primarily visible in the work of receptors that provoke spasms of the urethra and smooth muscles of the bladder. Because of this, a man cannot go to the toilet normally, and disturbances in the urination process are one of the main signs of prostate inflammation.

Alpha blockers are used as medicinal adjuncts in the treatment of inflammation of the prostate gland. They act in a targeted manner, promoting the relaxation of smooth muscle tissue, both the prostate and the bladder neck, with an increase in the outflow of urine. In this case, there is a significant reduction in the obvious symptoms of prostate enlargement.

During treatment, alpha blockers are introduced into the drug regimen to increase the effectiveness of the main drugs used. Therefore, in medical therapy they are classified as the second line of active drugs when necessary:

• reduce internal pressure in the urethra;
• reduce the tone of the smooth muscles of the prostate and bladder neck;
• increase the tone of a weakened bladder.

Alpha blockers for prostate pathology are designed to alleviate the course of the disease, but not cure it. This is purely symptomatic therapy. After their use, the following effects are observed:

• normalization of urine outflow;
• relaxation of smooth muscles with a decrease in pain;
• return of sexual desire;
• elimination of blood stagnation in the pelvis;
• reduction of manifestations of benign hyperplasia of the organ.

Classification of alpha adrenergic blockers

These medications are divided into:

• non-selective drugs that block both alpha-1 and alpha-2 adrenergic receptors (phentolamine, phenoxybenzamine);
• selective short-acting agents that block only alpha-1 receptors (prazosin);
• selective long-acting agents that can block only alpha-1 receptors (terazosin, doxazosin, alfuzosin);
• uroselective drugs (tamsulosin).

Selective agents do not require preliminary preparation and only in rare cases cause mild side effects. Despite the significant advantages, this type has one property that must be taken into account by men of reproductive age.

It has been established that under the influence of the active components of the drug, retrograde ejaculation develops, in which the release of seminal fluid occurs not into the urethra, but into the bladder. Let us consider in more detail all the drugs used to treat prostate pathologies.

However, most experts agree that selective drugs are somewhat better than non-selective drugs, since the latter have a stronger effect on the bladder and nervous system.

Tamsulosin

One of the most commonly used drugs. It has a selective effect on receptors in the male gland, bladder neck and prostatic urethra. In addition to the main properties of all blockers, it is capable of reducing the inflammatory reaction and obstruction in the organ.

Available in the form of capsules of 30 pcs. coated packaging with a dosage of the main substance - 0.4 mg. To treat prostatitis, you need to take 1 capsule 1 time per day during breakfast with 150 ml of water or milk.

The course of treatment is 2-3 months, depending on the instructions of the attending physician. The first effect occurs after 2 weeks of using the medicine.

• dizziness;
• tachycardia, orthostatic reactions;
• loss of appetite, nausea, vomiting, constipation;
• premature or retrograde ejaculation;
• itching, rash on the skin.

• hypersensitivity to the components of the product;
• tendency to hypotension with loss of consciousness;
• severe liver failure.

At the moment, Tamsulosin is the most popular representative of its group among doctors.

Doxazosin

Another selective alpha-1 receptor antagonist. It has a similar effect as the previous drug. The main difference and the reason for the significantly less popularity of this product is the need for titration during use.

Available in tablets of 1, 2, 4, 8 mg, 30 pieces per package. The average daily dose is 4 mg. You need to use 1 tablet 1 time per day with meals. The first week a dosage of 1 mg is prescribed, after 7 days - 2 mg and so on until the average norm is 4 mg. The course of therapy is 3 months.

• drowsiness, headache, asthenia (weakness);
• rhinitis, formation of peripheral edema;
• nausea, vomiting, diarrhea;
• extremely rarely - urinary incontinence.

Contraindications: allergies to the components of the medication.

It is worth saying that alpha-blockers in the acute course of the disease show poor results. This is due to the duration of the onset of the first effects. When using Doxazosin, their effect occurs only after 14 days, which is unforgivably long during acute manifestations.

Alfuzosin

The only popular and widely used non-selective alpha receptor blocker. It has all the same properties as its analogues, but has a number of disadvantages, due to which it is less often used in urology.

It basically affects all alpha receptors in the body. The result is relaxation of the smooth muscles of blood vessels (hypotension), intestines (constipation) and respiratory tract.

Available in the form of 5 mg tablets. The daily dose is 7.5-10 mg, depending on the severity of the disease and the prescription of the attending physician. You need to take 1/2 tablet (2.5 mg) 3 times a day with meals, drinking 200 ml of water. The course of therapy is 2-3 months. This medicine should not be combined with other drugs from the same group. In this case, the effect of both is neutralized.

• weakness, drowsiness, tinnitus, dizziness;
• tachycardia, orthostatic hypotension, exacerbation of angina pectoris;
• dry mouth, nausea, vomiting, constipation;
• itching and rash on the skin.

• allergy to the components of the drug;
• renal or liver failure;
• history of hypotension attacks.

The medicine is a non-selective drug and requires a gradual increase in the daily dosage. The amount of active substance during the first dose should not exceed 1 mg.

The dose is gradually increased to 10 mg during maintenance therapy and to 20 mg during treatment of inflammation of the prostate gland. The first results are felt 14 days after the start of the course.

It takes 1-1.5 months to achieve a sustainable clinical effect.

Terazosin is available in tablet form. It is recommended to drink them in the evening before bed. This will reduce the likelihood of side effects.

• asthenia;
• blurred vision;
• swelling of the mucous membranes of the respiratory organs;
• sexual dysfunction.

• allergy to the components of the drug;
• renal or liver failure;
• pathologies of the cardiovascular system.

Conclusion

Medicines in this group are very effective in relieving the main symptoms of inflammation of the prostate gland. However, it is necessary to understand that they can only serve as an addition to the main course of treatment.

Due to their long-term action, such drugs are much more effective for chronic prostatitis than for the acute phase of the disease. To avoid the development of serious adverse reactions, these medications should only be prescribed by your doctor.

Source: https://healthislife.ru/davlenie/preparaty-alfa-adrenoblokatory-pri-prostatite.html

Alpha adrenergic blockers - drugs for prostatitis: use, prices and reviews

Alpha adrenergic blockers for acute and chronic prostatitis make it possible to avoid surgical intervention in cases of severe urinary disturbance caused by spasm of the urethra and smooth muscles of the bladder.

These new generation drugs, when used, actively act on receptors that control the contraction and relaxation of blood vessels and muscles, restoring functionality and promoting their normal functioning.

Such blockers have found their use in urology, consumer reviews confirm this.

Features of therapy

Practicing doctors are well aware of the effect of prostatitis on urinary disorders in men. After all, the inflamed and swollen prostate gland compresses the walls of the bladder, which causes an increase in pressure in it, as well as the urinary ducts, leading to impaired outflow. This is associated with the following pathologies:

1. Increased pressure when closing the urethra.
2. Decreased rate of urination.
3. Incomplete dilation of the bladder neck.

Alpha adrenergic blockers, when used in the general treatment of prostatitis, eliminate the above disorders and normalize the outflow of urine. These drugs, when taken regularly as part of the complex treatment of prostatitis prescribed by a doctor, provide a good therapeutic effect.

It would be useful to recall once again that the choice of drugs and duration of treatment remains with the attending physician. Uncontrolled use of alpha adrenergic blockers is fraught with complications; these drugs, according to reviews, are very strong.

Classification and types of medicines

In urology, alpha adrenergic blockers are usually divided into groups so that their list is not too voluminous. This classification greatly facilitates the selection of drugs suitable for use in prostatitis, depending on the severity of its course, symptoms, age and general health of the patient. There are 4 groups in total:

• Selective short-acting blockers.
• Selective long-acting blockers.
• Non-selective blockers.
• Uroselective blockers.

Ask a urologist a question!

Kolokolov V.N.

The most famous selective short-acting drug is Prazosin, long-acting - Doxazosin, Alfuzosin, Terazosin. Doxazosin, as reviews say, is considered one of the most popular drugs prescribed for the treatment of dysfunction of the genitourinary system in men.

Its main effect is to relieve acute symptoms of prostatitis and normalize urination. This alpha1 adrenergic blocker actively reduces peripheral vascular resistance, which helps normalize the condition of the pelvic organs.

The side effects of drugs related to modern alpha-blockers include a decrease in visual acuity and the appearance of a variety of allergic reactions - from skin rashes to toxic edema.

Alfuzosin has a milder effect. The use of this alpha adrenergic blocker is indicated primarily for the treatment of chronic prostatitis. Its effect is invaluable - it quickly reduces pressure in the bladder and guarantees normal urination at any time of the day.

Terazosin has a similar therapeutic effect and is also actively used in the treatment of prostatitis. Its peculiarity is that its use, unlike other alpha blockers, does not cause attacks of tachycardia and has virtually no side effects.

But Tamsulosin is considered the most popular drug, closing the list of known drugs belonging to the new generation of alpha-blockers.

This helps to normalize the outflow of urine, as well as relieve acute symptoms of obstruction. And the use of this alpha adrenergic blocker, which is considered the best in its pharmacological group, helps relieve inflammation of the prostate gland and significantly reduce its swelling.

Any of the above remedies can only be taken as prescribed by a doctor. Such treatment will be effective and effective for prostatitis of any stage and form.

Price

The rather high prices that these blockers have are directly proportional to their effectiveness. They shouldn't be scary.

After all, these medications are necessary for a complete and final recovery from this unpleasant male illness.

Prices for the same product may vary in individual regions of Russia. In our table they will be shown based on data from the capital’s pharmacies.

Adrenergic blockers	Prices (RUB)
Prazosin 5 mg	3800,00
Alfuzosin 5 mg	2085,00
Terazosin 2 mg	313,00
Tamsulosin 4 mg	415,00
Doxazosin 4 mg	217,00

All of the above drugs have their own analogues. But before you give them preference, you need to consult your doctor. Only he can decide which adrenergic blockers will be effective in your case and how effective their use will be.

Advantages and disadvantages

Alpha adrenergic blockers are considered one of the most effective drugs used in urology for prostatitis.

These drugs effectively act on the receptors of the urethra and bladder, relieving their spasticity and tension.

And this, in turn, ensures normal urine outflow and completely eliminates the occurrence of congestion in the genitourinary system, which can lead to the development of purulent inflammation.

The advantages that adrenergic blockers have in the treatment of prostatitis are obvious. These include a pronounced therapeutic effect when used, which consists of the following:

• Relief of acute symptoms associated with impaired or painful urination.
• Reduced pressure when closing the urethra.
• Increasing the flow rate of the stream during urination.
• Reducing the frequency of relapses of urinary outflow disorders characteristic of chronic prostatitis.

As for the disadvantages that these blockers have, despite the fact that they are usually very well tolerated by men of all ages, they include the risk of side effects.

They, as a rule, are observed only in 10-15% of patients taking them as a course in the treatment of prostatitis and its complications.

The most common occurrences were dizziness, and less frequently, surges in blood pressure and heart rhythm disturbances.

Alpha adrenergic blockers are indicated for both acute and chronic forms of prostatitis. Their use is necessary for symptomatic treatment, since their analgesic effect is pronounced.

These blockers completely eliminate difficulty urinating, characteristic of this disease, since they actively relieve spasm and tension in the smooth muscles of the bladder and other organs of the genitourinary system.

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Source: https://mprostata.com/lechenie/lekarstva/alfa-adrenoblokatory-preparaty-pri-prostatite

Alpha-blockers for prostatitis ●list of the most effective + description ●

Many men think that health is given to them by nature and that it does not need any additional care. Very soon it becomes clear that this is not so, especially when the first signs of prostatitis begin to appear. To treat it, doctors use complex methods using alpha-blockers.

These medications are by far the safest and most effective treatments. With their help, you can completely cure the patient and relieve all symptoms, despite the fact that they belong to the drugs from the second line of treatment.

What is urethroprostatitis?

Alpha blockers for prostatitis

Doctors prescribe blockers to patients in three cases:

• due to decreased intraurethral pressure;
• when the tone of the prostate muscles becomes insufficient;
• with minimal bladder tone.

Official statistics show that a positive effect in treatment can be achieved in 50–85% of patients.

Adrenergic blockers for prostatitis are quite effective

Alpha blockers for prostate adenoma

Until recently, a diagnosis of prostate adenoma meant only one thing – resection.

Fortunately, advances in modern medicine make it possible to completely cure a patient of prostate adenoma without surgery.

With the help of alpha-blockers, doctors managed to revolutionize not only the methods of treating the disease, but also medical practice in general.

The nuances of taking Biseptol for prostatitis

Effect of alpha 1 adrenergic blockers for prostatitis

Medicines from this pharmacological group have a relaxing effect on the tissues and muscles of the genitourinary system.

The tone is reduced to normal, due to which the process of urination is normalized, and this, in turn, eliminates all the unpleasant symptoms of the disease.

Another of the many positive features that alpha blockers have is the ability to reduce the density of blood flow in the blood vessels.

In this case, reflex tachycardia does not develop in the patient. Adrenergic blockers also effectively reduce the symptoms of inflammation in all organs of the genitourinary system.

A-blockers for adenoma have the following effects on the body:

• completely eliminate false urge to urinate;
• relieve pain and thereby allow the patient to completely evacuate;
• relieve discomfort during bowel movements and more.

A positive effect after using the drugs is observed in 50-80% of men

Alpha-blockers for prostatitis, their effectiveness and tolerability by patients

During treatment, alpha blockers have a positive effect and normalize smooth muscle tone, and also normalize prostate volume. Adrenergic blockers do not have a negative effect on human hormonal levels.

A-blockers have a positive effect in treating the disease within a couple of weeks from its onset in 60% of patients. According to statistics, almost 100% of men who took these drugs tolerated all treatment without complications.

In any case, you need to know about all the side effects of blockers.

Beaver stream is a proven remedy for prostatitis

Alpha blockers for prostatitis and side effects

Considering the individual levels of norepinephrine and adrenaline in the body, as well as the presence of adrenergic receptors in the organs, the use of alpha blockers should only be prescribed by the attending physician.

Side effects are very rare, but nevertheless they can be as follows:

• weakness;
• drowsiness;
• headache and dizziness;
• dry mouth, weak stools, constant or partial nausea;
• severe discomfort in the intestines and abdomen.

However, these drugs have one rather specific effect: they cause retrograde ejaculation.

Medicines for the treatment of prostate adenoma in men

There are several effective ways to treat prostate adenoma, namely:

• treatment with proven traditional medicine;
• treatment by surgery;
• treatment with medications.

The choice of technique directly depends on the complexity and stage of the patient’s disease. As a rule, the symptoms of the disease can be eliminated in the initial stages using traditional medicine and medications. In cases where the disease is advanced, doctors resort to transurethral resection. Alpha blockers in the treatment of prostatitis are aimed at reducing the intensity of symptoms.

The most popular alpha 1 for prostatitis on the modern pharmaceutical market are:

• "Gitrin";
• "Kardura";
• "Flomax";
• Uroxatral.

Professional skills : Andrologist, Sexologist, Sexologist, Urologist, Reproductologist, Psychotherapist

Brief biography and personal achievements : Doctor of the highest category. Doctor of Medical Sciences. Acting Chief Physician and Scientific Director of his own proprietary scientific and practical clinic.

Doctor of Medical Sciences, urologist-andrologist, sexologist of the highest category, work experience of more than 20 years.

Professionally engaged in accurate diagnosis and treatment of various sexually transmitted infections, urethritis, prostatitis, prostate adenoma, premature ejaculation, erectile dysfunction, male menopause and infertility.

Consults and prescribes a treatment plan for decreased libido, excess weight, type 2 diabetes, and premature aging of men. He is a co-author of unique methods of complex treatment of prostate adenoma and prostatitis, thanks to which thousands of men over the past 10 years have avoided unwanted surgery.

Source: https://mensup.ru/zdorove/prostatit/alfa-adrenoblokatory-preparaty-pri-prostatite

Alpha blockers for prostatitis: list of drugs and application features

• Urologist-andrologist 1st category Petr Viktorovich
• 50858
• Update date: December 2019

Alpha blockers for prostatitis are drugs for the symptomatic treatment of urinary disorders. Medicines in this group do not affect the cause of the disease, but quickly relieve acute symptoms and improve quality of life. At the same time, they have a number of negative side effects and therefore require careful handling.

Operating principle

Drugs of this type can only be taken if they have been prescribed by the attending physician.

One of the most painful symptoms of prostate inflammation is the inability to fully empty the bladder. This phenomenon is caused by an increase in the muscle tone of the organ due to compression due to swelling of the prostate gland. It is to eliminate this symptom that drugs from the alpha-blocker group are used in urology.

The action of alpha blockers is aimed at reducing the sensitivity of receptors located in the smooth muscles of the bladder.

It should be noted that drugs in this group do not affect the inflammatory process in the prostate gland. Alpha-blockers for prostatitis only eliminate the consequences of prostate dysfunction, but do not treat prostatitis itself.

This explains the fact that in cases of sluggish congestive prostatitis, drugs of this group are practically not prescribed.

The main task of alpha-blockers for prostatitis is to facilitate the passage of urine, normalize urodynamics and at the same time prevent the development of acute urinary retention in acute bacterial prostatitis. Abuse of drugs in this group can have negative consequences for the entire body as a whole, so they can only be taken as prescribed by a urologist.

Classification of drugs

Drugs in this group are of two types - selective (selective) and non-selective (non-selective action).

The correct name for a group of drugs used in urology is alpha-1 adrenergic receptor blockers.

Non-selective alpha blockers are practically not used for prostatitis. This is due to the fact that such drugs affect all adrenergic receptors, which can lead to loss of bladder tone. Incontinence and urinary leakage may occur as a result of taking these medications.

Main drugs of the group

Dispensed only with a doctor's prescription

The most common alpha blockers in the treatment of prostatitis:

• tamsulosin;
• alfuzosin;
• doxazosin;
• Terazosin.

All these are names of the active substance; the commercial name of the drug may differ.

The listed drugs belong to the group of selective alpha-1 adrenergic receptor blockers. The principle of action of the drugs is the same, but they differ in the number of side effects and the degree of load on the liver and kidneys, which depends on the characteristics of the metabolism of the active substance.

The choice of medicine should be made by a doctor. You should not buy medicine on your own, based on reviews or the popularity of a particular name. Each specific case requires an individual approach.

Preparations based on tamsulosin

Among all the drugs from the group of alpha-blockers, the most popular for prostatitis are those based on tamsulosin hydrochloride. Commercial names of drugs:

• Tamsulosin Sandoz;
• Omnic;
• Omniprost;
• Adenorm.

All of the listed drugs are available in a dosage of 400 mg of active substance in one tablet. A distinctive feature of these drugs is the modified release of the active substance, which provides a prolonged effect from taking one therapeutic dose of the drug. This has a positive effect on the drug dosage regimen - only one tablet per day.

The most popular drug based on tamsulosin is the drug Omnic, however, it is significantly more expensive than other drugs with a similar composition.

The regimen for taking these medications is universal and does not require individual dosage selection.

The disadvantage of drugs with a modified release of the active component is the cumulative effect, and therefore the listed drugs have to be taken for quite a long time.

Thus, the stable therapeutic effect of drugs based on tamsulosin appears only after two weeks of regular use of the tablets.

Due to the fact that the metabolism of the active substance occurs in the liver, the listed drugs cannot be used by men with severe liver failure. In this case, you should consult your doctor about prescribing another medicine.

Alfuzosin in the treatment of prostatitis

When taking the tablet, you should swallow it whole.

Alfuzosin-based medications are prescribed much less frequently due to the large number of drug interactions and side effects. The main advantage of drugs based on this active ingredient over other drugs of the alpha-blocker group prescribed for prostatitis is less load on the liver.

Metabolism of the drug is carried out simultaneously by the liver and kidneys. However, alfuzosin-based drugs cannot be used to treat patients with severe renal and liver failure.

In case of mild violations on the part of these organs, the decision to prescribe this medicine should be made only by the attending physician.

Pharmacies offer three drugs based on this active ingredient - Dalfaz, Alfirum and Dalfusin. They are available in dosages of 5 and 10 mg of alfuzosin in one tablet. The dosage is selected individually for each patient; the tablet must be taken once a day. The drug acts quite quickly, the first effect is noticeable a day after the start of therapy.

Medicines based on doxazosin

The tablet should be taken once a day, without chewing.

This active substance is widely used to treat urodynamic disorders in prostatitis and prostate adenoma. The main disadvantage of the drug is the need to carefully select the dosage, with a weekly increase in the amount of the drug. Medicines based on this active ingredient:

• Doxazosin;
• Zoxon;
• Cardura.

Unlike other drugs in the group, drugs based on doxazosin do not have a prolonged effect, so the drug must be taken several times a day. The dosages of the listed drugs are 1, 2 and 4 mg of active ingredient in one tablet.

The medicine has a fairly large list of contraindications, one of which is obstruction of the upper urinary tract. This drug affects the tone of blood vessels and reduces blood pressure, therefore it is contraindicated in case of hypotension.

Terazosin for prostatitis

Another common drug is terazosin hydrochloride. The active substance belongs to the selective blockers of alpha-1 adrenergic receptors, due to which it is prescribed for prostatitis and prostate adenoma.

Preparations containing this active ingredient are Setegis, Terazosin-Teva. The product is available in different dosages - 1, 2, 5 or 10 mg of active ingredient in one tablet. The dosage is selected individually, but the medicine must be taken once a day.

The main feature of drugs based on terazosin hydrochloride is the absence of a pronounced effect on the functioning of the liver and kidneys. The medicine is not prohibited from being taken in case of renal and liver failure; in case of such disorders, it is only necessary to reduce the dosage.

Features of treatment with alpha blockers

Before you start taking a new drug, you should carefully study the instructions. Medicines to normalize urodynamics in prostatitis are prescribed with caution to patients over 65 years of age due to the risk of side effects, one of which is orthostatic hypertension.

It should be noted that while taking drugs of this group, retrograde ejaculation often develops. This disorder manifests itself as the reflux of seminal fluid into the bladder during ejaculation. This side effect is reversible and goes away some time after stopping the medication.

Despite the effectiveness of symptomatic therapy with alpha-1-blockers, the decision to prescribe drugs in this group should be made by a doctor. Self-medication can have negative health consequences.

Source: https://muzhik.guru/prostatit/lechenie/alfa-adrenoblokatory-pri-prostatite/

The use of alpha-blockers in the treatment of prostatitis

Drugs of the alpha-blocker group are included in the treatment of prostatitis as symptomatic agents . Their use increases the effectiveness of the medications used, delays surgical intervention, and improves the patient’s quality of life.

Efficiency of use for prostatitis

Adrenergic blockers (from the word “adrenaline”) are drugs that block adrenaline receptors, as a result of which they cease to perceive signals from the nervous system.

In the treatment of prostatitis, selective (selective action) alpha-blockers (α-blockers) acting on α1-adrenergic receptors are prescribed.

They are found in the smooth muscle tissues that form the walls of veins and arteries, the bladder, and the prostate.

When α1-adrenergic receptors are blocked, blood vessels and organs relax, drugs penetrate tissues more easily, thereby eliminating or alleviating the following symptoms of prostatitis :

1. Difficulty urinating, false urge.
2. Burning and aching in the groin.
3. Pain during ejaculation.
4. Deterioration of erection.

The use of alpha-blockers is advisable for chronic prostatitis. In the acute form, symptoms are relieved with non-steroidal anti-inflammatory drugs.

Drugs

List of drugs related to selective α1-blockers:

• Doxazosin: “Cardura”, “Kamiren”, “Artezin”, “Urocard”;
• Alfuzosin: Alfuprost, Dalfaz;
• Prazosin: "Polpressin";
• Silodosin: Urorek;
• Tamsulosin: “Proflosin”, “Omnik” (more about the treatment of prostatitis with “Omnik”), “Fokusin”, “Hyperprost”, “Omsulosin”, “Tulosin”;
• Terazosin: "Segetis", "Ternam".

α1-adrenergic receptor blocker; a drug for the symptomatic treatment of benign prostatic hyperplasia. Cost from 320 rubles in pharmacies of the Russian Federation.

Tamsulosin-based drugs are most often prescribed for the treatment of prostatitis . The drugs selectively relax the smooth muscles of the prostatic urethra, prostate gland, and bladder neck.

Tamsulosin has little effect on vascular contractility, so taking it does not affect blood pressure. Results in the form of relief of prostatitis symptoms in 50% of patients are noticeable within five days.

  After two weeks, the discomfort usually disappears completely.

Do drugs from the alpha-blocker group help you?

Source: https://muzhchina.info/prostata/prostatit/alfa-adrenoblokatory

Alpha adrenergic blockers: a list of drugs for the effective treatment of prostatitis

Prostatitis in any form is accompanied by tissue inflammation and compression of the bladder and urinary ducts. Because of this, difficulties arise with urination and urine retention in the body.

This phenomenon often leads to the spread of toxins in the pelvic tissues, and sometimes even promotes the crystallization of salts, provoking the growth of stones in the bladder.

Alpha-blockers are drugs for prostatitis, allowing you to avoid a surgical solution to the problem of urinary retention.

Characteristics and properties of drugs

Alpha adrenergic blockers (AABs) are a group of drugs that allow you to partially or completely block the functioning of receptors in the body that interact with adrenaline and norepinephrine. As a result, there is a decrease in the activity of the sympathetic nervous system.

All AAB are divided into 2 groups:

• non-selective, acting on alpha-1 and alpha-2 adrenergic receptors;
• selective, acting on alpha-1 adrenergic receptors.

When used, non-selective AABs completely block the functioning of receptors, while selective ones partially block them.

For simplest symptoms, the doctor often prescribes alpha-blockers

Indications for use

The main indications for the use of selective alpha-blockers for prostatitis is a violation of the outflow of urine. Also, drugs of this type are used for the following pathologies:

• arterial hypertension;
• chronic heart failure in the initial stage of development;
• adenoma and benign prostatic hyperplasia, accompanied by problems with urination.

Important! Non-selective AABs are used to treat hypertensive crises, in particular when a brain tumor is suspected.

Mechanism of action

When they enter the body, blockers temporarily block the ability of adrenergic receptors to transmit nerve impulses using catecholamines. In this case, feedback from the receptors is not blocked.

In the human body, alpha1-adrenergic receptors are located in small arteries. Thanks to the blockers acting on them, blood pressure and manifestations of vascular spasms are reduced.

A subset of them, alpha-1a adrenergic receptors, are found in the bladder neck, prostate gland and urethra. When they are blocked, the smooth muscles of the urinary system relax, and the process of urination is greatly facilitated.

Alpha-2 adrenergic receptors are found at neuromuscular junctions. They are responsible for converting nerve impulses into muscle contractions. When these receptors are blocked, the level of norepinephrine increases, which leads to dilation of the arteries of most internal organs. By affecting the organs of the genitourinary system, alpha-2 receptor blockers provoke increased erection.

To treat inflammatory processes in the prostate, alpha-blockers of the selective group are predominantly used, since they have minimal effect on other organs.

Popular alpha blockers

The list of alpha-blocker drugs is huge. However, not all of them can be used in the treatment of urological pathologies.

Alpha-1 blockers are used exclusively in urology:

1. Alfuzosin. A non-selective drug that is highly effective in eliminating urinary problems. However, the drug is absolutely incompatible with other AABs and most medications for hypertension. The price per package of the drug ranges from 2085-2732 rubles.
2. Tamsulosin (Omnic). This selective drug not only improves urine flow and relaxes the smooth muscles of the bladder, but also actively helps eliminate inflammation and symptoms of obstruction. The medicine should be taken only after breakfast. The cost of packaging is 415-583 rubles.

Both drugs act exclusively on the alpha-1a receptor subgroup and have virtually no effect on blood pressure levels.

When treating prostate pathologies and problems with the cardiovascular system, AABs are most often used:

1. Doxazosin. These tablets for prostatitis not only improve the flow of urine, but also reduce the manifestations of benign prostatic hyperplasia. Prices for the drug range from 219-346 rubles.
2. Terazosin. It is a new generation non-selective medicine. It does not increase the load on the heart muscle. Terazosin should only be taken at night, just before bedtime. After taking the medicine, you must stay in bed for several hours without getting up. The price per package is 319-501 rubles.

The duration of the therapeutic course, as well as the dosage, are prescribed by the doctor strictly individually.

Source: https://prostatu.guru/preparaty/nedorogie-i-effektivnye-alfa-adrenoblokatory-pri-prostatite.html